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Year : 2020  |  Volume : 86  |  Issue : 1  |  Page : 24--32

A retrospective study: Clinicopathological and immunohistochemical analysis of 54 cases of tufted angioma

Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shanxi Province, China

Correspondence Address:
Prof. Cuiling Ma
Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shanxi Province 710032
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijdvl.IJDVL_777_18

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Background: Tufted angioma is a rare benign lesion with vascular proliferation. Aim: To retrospectively analyze the clinicopathological manifestations and immunohistochemical features of tufted angioma. Methods: Clinical and histopathological features of tufted angioma (n = 54) were evaluated and analyzed retrospectively in the Department of Dermatology, Xijing Hospital from 2003 to 2014. Results: Clinically, tufted angioma usually presented as erythematous plaques and papules on the head and neck (n = 11), trunk (n = 21) and extremities (n = 22), mainly in children (n = 48), without gender difference (24 males and 30 females). A total of 45 cases showed solitary lesions and nine cases showed multiple lesions. Common symptoms included pain (n = 11), tenderness (n = 7), itching (n = 1), hypertrichosis (n = 7), hyperhidrosis (n = 6) and Kasabach–Merritt phenomenon (n = 1). Histopathologically, typical tufted angioma (n = 37) showed proliferation of endothelial cells in a so-called cannonball pattern, while in the early (n = 4) and regressed (n = 13) stages the tufted appearance was not prominent. The proliferated endothelial cells were diffusely positive for CD31 and Wilms tumor 1, focally positive for D2-40 and Prox1, and negative for Glut-1. Limitations: Our research was confined to patients of Chinese origin and our sample size was limited. Conclusions: Tufted angioma is a rare vascular neoplasm with diverse clinical manifestations and unique pathological features. It should be recognized as a vascular tumor with lymphatic differentiation. We emphasize the importance of considering tufted angioma in the differential diagnoses of any congenital or acquired vascular tumor.


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