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LETTERS TO THE EDITOR - LETTER IN RESPONSE TO PREVIOUSLY PUBLISHED ARTICLES
Year : 2019  |  Volume : 85  |  Issue : 3  |  Page : 313-314

Transepidermal elimination: Role in leprosy transmission


Department of Dermatology and Venereology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India

Date of Web Publication19-Apr-2019

Correspondence Address:
Dr. Naveen Kumar Kansal
Department of Dermatology and Venereology, All India Institute of Medical Sciences, Rishikesh - 249 203, Uttarakhand
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijdvl.IJDVL_877_18

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How to cite this article:
Kansal NK. Transepidermal elimination: Role in leprosy transmission. Indian J Dermatol Venereol Leprol 2019;85:313-4

How to cite this URL:
Kansal NK. Transepidermal elimination: Role in leprosy transmission. Indian J Dermatol Venereol Leprol [serial online] 2019 [cited 2019 Sep 20];85:313-4. Available from: http://www.ijdvl.com/text.asp?2019/85/3/313/253353




Sir,

I read with interest the Residents' Page article by Shah et al. on transepidermal elimination.[1] Though transepidermal elimination in leprosy was mentioned only once, I would like to make a few comments about the significance of this phenomenon in histoid (and lepromatous) leprosy.[1]

Nasal discharge from the untreated leprosy patient is considered the usual source of infection in the community and the cutaneous route is said to be unimportant. In tuberculoid leprosy, Mycobacterium leprae resides largely within the skin and the nerve and these patients are never considered infectious.

However, a number of workers have reported the presence of acid-fast bacilli in the epidermis.[2],[3],[4],[5] Namisato et al. proposed transepidermal elimination as a mechanism for a “mass transport” of live leprosy bacilli in an untreated 35-year-old male lepromatous patient.[6] The umbilicated/molluscoid lesion is one of the rarest morphological types of histoid leprosy. The fact that type 2 (pseudoisomorphic) Köebner's phenomenon has been reported in this form of histoid leprosy further substantiates the fact that viable bacilli must be eliminated transepidermally for this to occur clinically.[7] Therefore, the skin may definitely be a portal for leprosy transmission, at least in the multibacillary cases. Studies are required to explore the contribution of cutaneous carriage and role of epidermal elimination of the bacilli in leprosy transmission. The need is acute as the multibacillary histoid and lepromatous cases are definitely a dreaded challenge to the elimination of this chronic mutilating disease.[8],[9]

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Shah H, Tiwary AK, Kumar P. Transepidermal elimination: Historical evolution, pathogenesis and nosology. Indian J Dermatol Venereol Leprol 2018;84:753-7.  Back to cited text no. 1
[PUBMED]  [Full text]  
2.
Okada S, Komura J, Nishiura M. Mycobacterium leprae found in epidermal cells by electron microscopy. Int J Lepr Other Mycobact Dis 1978;46:30-4.  Back to cited text no. 2
    
3.
Ghorpade AK. Transepidermal elimination of Mycobacterium leprae in histoid leprosy: A case report suggesting possible participation of skin in leprosy transmission. Indian J Dermatol Venereol Leprol 2011;77:59-61.  Back to cited text no. 3
[PUBMED]  [Full text]  
4.
Chander R, Jabeen M, Malik M. Molluscum contagiosum-like lesions in histoid leprosy in a 10-year-old Indian boy. Pediatr Dermatol 2013;30:e261-2.  Back to cited text no. 4
    
5.
Job CK, Jayakumar J, Kearney M, Gillis TP. Transmission of leprosy: A study of skin and nasal secretions of household contacts of leprosy patients using PCR. Am J Trop Med Hyg 2008;78:518-21.  Back to cited text no. 5
    
6.
Namisato M, Kakuta M, Kawatsu K, Obara A, Izumi S, Ogawa H. Transepidermal elimination of lepromatous granuloma: A mechanism for mass transport of viable bacilli. Lepr Rev 1997;68:167-72.  Back to cited text no. 6
    
7.
Ghorpade A. Molluscoid skin lesions in histoid leprosy with pseudo-isomorphic Koebner phenomenon. Int J Dermatol 2008;47:1278-80.  Back to cited text no. 7
    
8.
Sales AM, Ponce de Leon A, Düppre NC, Hacker MA, Nery JA, Sarno EN, et al. Leprosy among patient contacts: A multilevel study of risk factors. PLoS Negl Trop Dis 2011;5:e1013.  Back to cited text no. 8
    
9.
Palit A, Inamadar AC. Histoid leprosy as reservoir of the disease; a challenge to leprosy elimination. Lepr Rev 2007;78:47-9.  Back to cited text no. 9
    




 

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