IADVL
Indexed with PubMed and Science Citation Index (E) 
 
Users online: 1738 
     Home | Feedback | Login 
About Current Issue Archive Ahead of print Search Instructions Online Submission Subscribe What's New Contact  
  NAVIGATE Here 
    Next article
    Previous article
    Table of Contents

 RESOURCE Links
    Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
  Related articles
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed597    
    Printed32    
    Emailed0    
    PDF Downloaded41    
    Comments [Add]    

Recommend this journal

 

 BRIEF REPORT
Year : 2019  |  Volume : 85  |  Issue : 3  |  Page : 300--304

Effect of low-dose acitretin treatment on pituitary hormones in psoriasis vulgaris: A retrospective study


1 Department of Dermatology, Istanbul Medeniyet University, School of Medicine, Istanbul, Turkey
2 Department of Dermatology, Duzce University, School of Medicine, Duzce, Turkey
3 Department of Internal Medicine, Istanbul Medeniyet University, School of Medicine, Istanbul, Turkey
4 Department of Dermatology, Van Yuzuncu Yil University, Van, Turkey
5 Department of Biochemistry, Van Yuzuncu Yil University, Van, Turkey
6 Department of Endocrinology, Kecioren Research and Training Hospital, Ankara, Turkey

Correspondence Address:
Dr. Ayse Serap Karadag
Department of Dermatology, Medeniyet University Faculty of Medicine, Istanbul 34730
Turkey
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijdvl.IJDVL_628_17

Rights and Permissions

Background: It has been reported that retinoids may lead to hormonal alterations. Aim: In this retrospective study, we aimed to study the effect of acitretin on pituitary hormones in psoriasis patients. Methods: Out of 50 patients intended to be studied, blood samples of 43 patients could be tested before and after 3 months of acitretin therapy (0.2 to 0.5 mg/kg/day). Results: Patients mean ± standard deviation ages and female/male ratio were 46 ± 17 years and 19/24, respectively. After treatment with acitretin, gamma-glutamyltransferase, alkaline phosphatase, total cholesterol and triglyceride levels increased significantly (P < 0.05). After treatment, total protein, free thyroxine (T4) levels decreased significantly (P < 0.05). No significant differences were observed between before–after acitretin treatment regarding pituitary hormone levels in psoriasis patients (P > 0.05). Limitations: The retrospective nature of the study, inability to retest blood samples of 7 patients at 3 months post treatment, low dose and short duration of acitretin treatment were limitations of this study. Conclusion: This study showed that pituitary hormones were not affected except free T4 (thyroid hormone) by acitretin treatment. Further experimental and clinical studies are needed to clarify the effect of acitretin on pituitary hormones.






[FULL TEXT] [PDF]*


        
Print this article     Email this article

Online since 15th March '04
Published by Wolters Kluwer - Medknow