IADVL
Indexed with PubMed and Science Citation Index (E) 
 
Users online: 4590 
     Home | Feedback | Login 
About Current Issue Archive Ahead of print Search Instructions Online Submission Subscribe What's New Contact  
  NAVIGATE Here 
    Next article
    Previous article
    Table of Contents

 RESOURCE Links
    Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
  Related articles
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed863    
    Printed40    
    Emailed0    
    PDF Downloaded100    
    Comments [Add]    

Recommend this journal

 

 ORIGINAL ARTICLE
Year : 2019  |  Volume : 85  |  Issue : 2  |  Page : 153--159

Linking of psoriasis with osteopenia and osteoporosis: A cross-sectional study


1 General Dermatology Department, Dermatology Unit, Virgin de las Nieves University Hospital, Granada, Spain
2 General Medicine Department, Community Medicine Unit, Virgen de las Nieves University Hospital, Granada, Spain
3 Osteoporosis Department, Endocrinology Unit, Virgen de las Nieves University Hospital, Granada, Spain
4 General Orthophedics Department, Orthopedics Unit, Virgen de las Nieves University Hospital, Granada, Spain
5 Dermatology Department, Medicine School of the University of Granada, Granada, Spain
6 General Dermatology Department, Dermatology Unit, Virgin de las Nieves University Hospital; Dermatology Department, Medicine School of the University of Granada, Granada, Spain

Correspondence Address:
Dr. Antonio Martinez-Lopez
Av de la Ilustracion, 65, 5°A, 18016, Granada
Spain
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijdvl.IJDVL_831_17

Rights and Permissions

Background/Purpose: Psoriasis is a multisystem disease which has been related to vitamin-D deficiency through chronic inflammation. This psoriasis-related inflammatory state and vitamin-D deficiency may induce bone mineral density loss. The purpose of this study is to assess the relationship of psoriasis with bone mineral density, by comparing psoriatic patients with healthy controls and patients with osteopenia/osteoporosis. Methods: A total of 185 subjects were studied; 58 psoriatic patients who had not been under systemic or biological treatment were included. Age, gender, body mass index, phosphocalcic metabolic parameters and hip and lumbar (L4) bone mineral density data were collected. These variables were compared with those collected in 61 healthy controls and 67 patients with osteopenia/osteoporosis. Results: Psoriatic patients showed worse hip and lumbar spine bone mineral density levels than healthy controls (P = 0.001) and better levels than osteoporotic patients (P < 0.001). Multivariate analysis demonstrated a negative association of age and a positive association of body mass index in hip bone mineral density in psoriatic patients. Limitations: The main limitations are those of cross-sectional studies, such as a lack of follow up period, and a male predominance in the psoriatic group, which is corrected employing a multivariate analysis with an adjusted model for confounding factors. Conclusions: Bone mineral density levels in psoriatic patients are situated halfway between healthy controls and patients with osteopenia/osteoporosis. In addition, the higher body mass index in patients with psoriasis appears to confer a protective effect against further development of lower bone mineral density.






[FULL TEXT] [PDF]*


        
Print this article     Email this article

Online since 15th March '04
Published by Wolters Kluwer - Medknow