| ORIGINAL ARTICLE
|Year : 2019 | Volume
| Issue : 1 | Page : 51--55
Toenail concentrations of zinc, selenium and nickel in patients with chronic recurrent warts: A pilot two-group comparative study
Mohamed El-Komy1, Vanessa Hafez1, Rania Abdel Hay1, Dina Mehaney2, Iman Hafez3
1 Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt
2 Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Cairo, Egypt
3 Egyptian Health Insurance Organization, Egypt
Background: Normal immune functioning requires sufficient levels of trace elements including zinc and selenium, while elements such as nickel can be immunotoxic.
Aim: To assess long-term abnormalities in zinc, selenium and nickel levels in patients with chronic recurrent warts.
Methods: Toenail samples were taken from 28 patients with chronic recurrent warts and 30 apparently healthy matching controls were analysed. Toenail concentrations of zinc, selenium and nickel were measured using inductively-coupled plasma-optical emission spectroscopy.
Results: Selenium levels were significantly higher in patients than in controls (P = 0.03). Levels of trace elements did not correlate with the number or duration of warts. Toenail nickel levels in all subjects were higher than globally reported values.
Limitations: A small sample size and the absence of regional reference ranges for concentrations of trace elements in toenails.
Conclusion: Zinc does not seem to be involved in the chronicity of warts, and it is unclear if selenium has a protective role against warts. Our finding of high concentrations of nickel in both patients and controls raises concerns about environmental exposure.
Dr. Rania Abdel Hay
13th Abrag Othman, Kournish El Maadi, Cairo 11431
Source of Support: None, Conflict of Interest: None
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