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 Table of Contents    
Year : 2018  |  Volume : 84  |  Issue : 5  |  Page : 583

Letter in response to the previously published article “Familial gigantic melanocytosis”

Department of Dermatology, Dr. V. P. Medical College and Hospital and Research Centre, Nashik, Maharashtra, India

Date of Web Publication03-Aug-2018

Correspondence Address:
Dr. Manoj Pawar
Department of Dermatology, Dr. V. P. Medical College and Hospital and Research Centre, Nashik - 422 003, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijdvl.IJDVL_273_18

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How to cite this article:
Pawar M. Letter in response to the previously published article “Familial gigantic melanocytosis”. Indian J Dermatol Venereol Leprol 2018;84:583

How to cite this URL:
Pawar M. Letter in response to the previously published article “Familial gigantic melanocytosis”. Indian J Dermatol Venereol Leprol [serial online] 2018 [cited 2020 May 27];84:583. Available from: http://www.ijdvl.com/text.asp?2018/84/5/583/238505


I read with great interest the case letter by Rambhia et al. on “Familial gigantic melanocytosis.”[1] As reported, their patient presented with diffuse reticulate hyperpigmentation along with interspersed guttate hypopigmentation and light-colored hair; authors thought of differential diagnosis such as lichen planus pigmentosus, erythema dyschromicum perstans and dyschromatosis universalis hereditaria. However, except the latter condition, the above cutaneous findings do not fit into the former two disease entities, i.e., lichen planus pigmentosus and erythema dyschromicum perstans. Lichen planus pigmentosus presents with persistent and asymptomatic slate-gray pigmentation, predominantly on the sun-exposed parts, whereas erythema dyschromicum perstans is characterized by asymptomatic, ashy-gray, macular hyperpigmentation of the skin and the expanding macules have a slightly raised, erythematous border in the initial inflammatory stage.[2] Instead of these two conditions, authors should have considered Griscelli syndrome type 3 and antimalarial-induced pigmentation, and of course, familial gigantic melanocytosis, as all these three entities present with diffuse hyperpigmentation with guttate hypomelanosis and light-colored hairs.[3] Griscelli syndrome type 3 is characterized by irregular clusters of melanin pigment scattered throughout the hair shaft observed on hair microscopy.[4] This begs two questions: Whether the hair microscopy was performed in the patient, and was there a history of intake of any antimalarial drug? Also, the other closer differentials should include Fanconi anemia, biliary cirrhosis and hemochromatosis, as diffuse hyperpigmentation with guttate hypomelanosis is present in these disorders but the hair is normal; instead, there will be pancytopenia, pruritus and iron overload, respectively.[5]

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  References Top

Rambhia KD, Chowdhary KS, Rao GV, Khopkar US. Familial gigantic melanocytosis. Indian J Dermatol Venereol Leprol 2018;84:192-4.  Back to cited text no. 1
[PUBMED]  [Full text]  
Chandran V, Kumarasinghe SP. Macular pigmentation of uncertain aetiology revisited: Two case reports and a proposed algorithm for clinical classification. Australas J Dermatol 2017;58:45-9.  Back to cited text no. 2
El-Darouti MA. Diffuse pigmentation with guttate hypomelanosis in an anemic patient. In: Challenging Cases in Dermatology. London: Springer; 2013.  Back to cited text no. 3
Nouriel A, Zisquit J, Helfand AM, Anikster Y, Greenberger S. Griscelli syndrome type 3: Two new cases and review of the literature. Pediatr Dermatol 2015;32:e245-8.  Back to cited text no. 4
El-Darouti MA, Fawzi SA, Marzook SA, El-Eishi NH, Abdel-Halim MR, Soliman SA, et al. Familial gigantic melanocytosis. Int J Dermatol 2005;44:1010-5.  Back to cited text no. 5


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