IADVL
Indexed with PubMed and Science Citation Index (E) 
 
Users online: 785 
     Home | Feedback | Login 
About Current Issue Archive Ahead of print Search Instructions Online Submission Subscribe What's New Contact  
  Navigate here 
  Search
 
  
 Resource links
   Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
   Article in PDF (886 KB)
   Citation Manager
   Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
* Registration required (free)  

 
  In this article
   References
   Article Figures
   Article Tables

 Article Access Statistics
    Viewed2082    
    Printed42    
    Emailed0    
    PDF Downloaded81    
    Comments [Add]    

Recommend this journal

 


 
 Table of Contents    
LETTER TO THE EDITOR - STUDY LETTER
Year : 2018  |  Volume : 84  |  Issue : 2  |  Page : 205-208

Clinical experience of adalimumab in the treatment of psoriasis - A 10-year journey in a tertiary dermatology centre


Department of Dermatology, National Skin Centre, 308205, Singapore

Date of Web Publication07-Feb-2018

Correspondence Address:
Dr. Wai Man Mandy Chan
Department of Dermatology, National Skin Centre, 1 Mandalay Road, 308205
Singapore
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijdvl.IJDVL_163_17

Rights and Permissions



How to cite this article:
Mandy Chan WM, Oon HH, Chong WS. Clinical experience of adalimumab in the treatment of psoriasis - A 10-year journey in a tertiary dermatology centre. Indian J Dermatol Venereol Leprol 2018;84:205-8

How to cite this URL:
Mandy Chan WM, Oon HH, Chong WS. Clinical experience of adalimumab in the treatment of psoriasis - A 10-year journey in a tertiary dermatology centre. Indian J Dermatol Venereol Leprol [serial online] 2018 [cited 2019 Dec 14];84:205-8. Available from: http://www.ijdvl.com/text.asp?2018/84/2/205/224890


Sir,

Adalimumab is a recombinant human immunoglobulin monoclonal antibody, which inhibits tumor necrosis factor-alpha (TNFα). It is approved for use in moderate-to-severe psoriasis vulgaris and psoriatic arthritis by the United States Food and Drug Administration.

Randomized control trials (RCTs) have shown that adalimumab is efficacious and well-tolerated, with efficacy maintained over more than 5 years of treatment.[1] However, conducted RCTs have strict inclusion, exclusion, and predefined continuation and discontinuation criteria, making it difficult to extrapolate the data for use in real-world daily practice. This retrospective study aims to examine the safety and efficacy of adalimumab in daily practice over its 10-year use in psoriasis patients in a tertiary dermatology centre.

The case records of psoriasis patients who were prescribed adalimumab were retrieved and analyzed from the institutional electronic database from September 2006 to August 2016. Demographic data and disease specific data collected included age, sex, disease duration, prior systemic or biologic use, baseline screening, psoriasis area and severity index (PASI) score, body surface area (BSA), and adverse events.

All patients underwent baseline full blood count, creatinine, liver function, chest radiograph, hepatitis B and C screening, with Mantoux and/or T-SPOT.TB test.

Patients with chronic plaque psoriasis and generalized pustular psoriasis were studied. Patients with pure psoriatic arthritis were not included. Treatment aim was to improve moderate to severe chronic plaque psoriasis. Biologics were indicated for patients with moderate-to-severe plaque psoriasis (PASI >10 or BSA >10%) who failed to respond or had contraindications to standard systemic therapy or phototherapy. Adalimumab was dosed at 80 mg subcutaneously at week 0, followed by 40 mg at week 1, and 40 mg every-other-week. This study was approved by the local institutional ethics review committee.

The primary efficacy was determined at 16 weeks, in line with other studies comparing efficacy; further progress and adverse events were monitored in patient follow-up through their electronic medical records.[2] Efficacy assessments included the proportion of patients achieving at least 75% reduction in PASI (PASI75) compared to baseline at week 16. PASI and BSA were not uniformly recorded after 16 weeks of treatment.

Baseline characteristics of patients were summarized using descriptive statistics. Wilcoxon signed-rank test was used to evaluate PASI and BSA scores at baseline and week 16. Statistical significance was set at P < 0.05. For safety evaluation, adverse effects of the treatment were summarized. Statistics were computed using Stata Version 14.1, StataCorp LP, USA.

Fourty-five patients were enrolled, and background characteristics and demographics are summarized in [Table 1]. Mean treatment duration was 46.1 weeks. Thirty-three patients (73.3%) were no longer on adalimumab at the time of data collection, with 14 patients (42.4%) citing cost as the reason for stopping treatment.
Table 1: Patient characteristics (n=45)

Click here to view


There was a significant improvement in PASI score from mean PASI of 19.3 to 5.1 at 16 weeks (P < 0.001) [Figure 1]. BSA dropped from the baseline mean of 32.9 to 9.9 at week 16 (P < 0.001).
Figure 1: Mean Psoriasis Area and Severity Index score before and after 16 weeks of adalimumab

Click here to view


Eighteen patients (40%) had active psoriatic arthritis prior to treatment with adalimumab, and 16 of these (88.9%) had subjective improvement in joint pains while on adalimumab, although psoriatic arthritis disease activity scores and radiological response were not recorded.

Two patients with generalized pustular psoriasis were treated with adalimumab. One patient received acitretin, methotrexate, cyclosporine, and isotretinoin with suboptimal control prior to treatment with adalimumab. Baseline BSA was 70% and improved to 5% at week 16. The second patient failed cyclosporine with methotrexate therapy and BSA improved from 20% to 5% after 16 weeks of adalimumab.

Prior and concurrent therapy with adalimumab is described in [Table 2]. Twenty-eight patients (62.2%) were biologic-naïve at the start of adalimumab therapy. Those who had previous biologic therapies are presented in [Table 2]. The number of patients who had received different biologics previously varied from 0 to 5. The difference in PASI75 at 16 weeks were not significant between biologic-naïve and nonbiologic-naïve patients (P = 0.060) [Figure 2].
Figure 2: Comparing Psoriasis Area and Severity Index in biologic-naive and biologic nonnaive patients

Click here to view
Table 2: Concurrent and prior treatment before adalimumab (n=45)

Click here to view


Five patients (11.1%) stopped treatment due to side effects: these include urinary sepsis, transaminitis, pulmonary tuberculosis (TB), and pneumonia [Table 3]; of note, two patients developed TB. Both patients were self-funded on adalimumab, one being an Indian male who restarted adalimumab after 6 months of anti-TB treatment, and the other a Chinese female who discontinued adalimumab after anti-TB treatment. Three patients had reactive T-SPOT.TB test (after initial negative test) after treatment with adalimumab and were treated with isoniazid for latent tuberculosis infection. It is important to screen for TB, especially in South-East Asia, where TB risk is high with an estimated incidence of 36.9 per 100,000 population.[3] Compared to other biologics in our centre (unpublished data), 2 out of 10 patients were treated for latent tuberculosis infection prior to initiation of infliximab, and 11 out of 99 patients were treated for latent tuberculosis infection prior to treatment with ustekinumab. None of these patients developed pulmonary TB while on respective biologic treatment. As part of our biologic guidelines, we screen all patients on biologics annually with an interferon gamma release assay such as T-SPOT.TB blood test.
Table 3: Adverse events

Click here to view


We were unable to find any previous reports reviewing the safety and efficacy of adalimumab in the treatment of psoriasis patients in Singapore. Our results show that 77.8% of the patients achieved PASI75 at week 16 of therapy, which is similar to other published reports.[2] One patient has been receiving adalimumab for 7.9 years, and is currently still on adalimumab with good response.

Overall, adalimumab proved to be relatively safe and generally well tolerated. It is important to screen for TB, especially in South-East Asia. All patients in our centre are screened annually with an interferon gamma release assay test.

Two of our patients with generalized pustular psoriasis who failed conventional therapy were treated successfully with adalimumab. Anti-TNFα therapy in psoriasis has been associated with worsening of psoriasis, erythrodermic flare, and development of palmoplantar pustulosis, but this was not observed in our study.[4]

Eight (15.6%) patients stopped adalimumab due to lack of efficacy, and the mean treatment duration was 24 weeks for nonresponders. These rates are similar to other randomized as well as open-label studies.[5]

Limitations to this study include its retrospective nature, no control group, and small study cohort. The PASI score was not uniformly recorded at every subsequent visit, and therefore, we were unable to compare efficacy with prolonged treatment. Adalimumab antibodies were not studied.

In conclusion, we demonstrate that adalimumab is effective and safe in the treatment of psoriasis and suggest important parameters to screen and monitor for in our population.

Acknowledgement

We acknowledge and thank Ms. Virlynn Tan, biostatistician, Research Department, National Skin Centre, for her statistical input.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Menter A, Thaçi D, Papp KA, Wu JJ, Bereswill M, Teixeira HD, et al. Five-year analysis from the ESPRIT 10-year postmarketing surveillance registry of adalimumab treatment for moderate to severe psoriasis. J Am Acad Dermatol 2015;73:410-9.e6.  Back to cited text no. 1
    
2.
Gordon KB, Langley RG, Leonardi C, Toth D, Menter MA, Kang S, et al. Clinical response to adalimumab treatment in patients with moderate to severe psoriasis: Double-blind, randomized controlled trial and open-label extension study. J Am Acad Dermatol 2006;55:598-606.  Back to cited text no. 2
[PUBMED]    
3.
Ministry of Health Communicable Diseases Surveillance in Singapore; 2014. Available from: https://www.moh.gov.sg/content/dam/moh_web/Publications/Reports/2015/HIV-AIDS%20STIs%20Tuberculosis%20Leprosy.pdf. [Last accessed on 2017 May 28].  Back to cited text no. 3
    
4.
Shmidt E, Wetter DA, Ferguson SB, Pittelkow MR. Psoriasis and palmoplantar pustulosis associated with tumor necrosis factor-α inhibitors: The Mayo Clinic experience, 1998 to 2010. J Am Acad Dermatol 2012;67:e179-85.  Back to cited text no. 4
[PUBMED]    
5.
Fotiadou C, Lazaridou E, Sotiriou E, Ioannides D. Adalimumab for psoriasis in Greece: Clinical experience in a tertiary referral centre. J Eur Acad Dermatol Venereol 2012;26:1298-303.  Back to cited text no. 5
[PUBMED]    


    Figures

  [Figure 1], [Figure 2]
 
 
    Tables

  [Table 1], [Table 2], [Table 3]



 

Top
Print this article  Email this article

    

Online since 15th March '04
Published by Wolters Kluwer - Medknow