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  Introduction
   Endocrine-Disrup...
  Discussion
  Conclusion
   References

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VIEWPOINT
Year : 2017  |  Volume : 83  |  Issue : 5  |  Page : 522-524

Chemical environmental factors: Can they affect acne?


Faculty of Medicine, National and Kapodistrian University of Athens, Athens, Greece

Date of Web Publication07-Aug-2017

Correspondence Address:
Maria Mazioti
26, Perikleous Street, Salamina, Athens 18900
Greece
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijdvl.IJDVL_736_16

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How to cite this article:
Mazioti M. Chemical environmental factors: Can they affect acne?. Indian J Dermatol Venereol Leprol 2017;83:522-4

How to cite this URL:
Mazioti M. Chemical environmental factors: Can they affect acne?. Indian J Dermatol Venereol Leprol [serial online] 2017 [cited 2017 Aug 20];83:522-4. Available from: http://www.ijdvl.com/text.asp?2017/83/5/522/210641



  Introduction Top


Acne vulgaris represents a skin disorder characterized by chronic inflammation of the pilosebaceous units.[1] Acne affects nearly 80% of the adolescent population,[2] but persists into the 20s and 30s in 64% and 43% of adults respectively.[3] Furthermore, epidemiological evidence suggests that its prevalence is considerably higher in industrialized societies due to the changes in lifestyle and the influence of environmental factors on individuals with genetic predisposition.[4] Androgens have been long incriminated in the pathogenesis of acne as evidenced by onset at puberty (when excess androgen activity is observed)[5],[6] and presentation in association with hyperandrogenism.[7] The relation of acne and androgens is further supported by studies showing that castrated men or eunuchs do not develop acne and that postadolescent resection of gonads or treatment with antiandrogens decreases sebum production and ameliorates acne.[8],[9],[10]

Endocrine-disrupting chemicals are defined as exogenous factors interfering with synthesis, secretion, transport, metabolism, binding or elimination of natural hormones. Endocrine-disrupting chemicals are widely used in the production of industrial, pharmaceuticals and personal care products. Exposure to endocrine-disrupting chemicals even in small concentrations can lead to endocrine disorders such as the imbalance of sex hormones.[11]

Several endocrine-disrupting chemicals which exist ubiquitously in the environment may induce excess androgenic stimulation or elevated androgen levels. Since androgens play a pivotal role in acne, the present article suggests that exposure to endocrine-disrupting chemicals, in combination with other agents, may be a crucial factor for acne pathogenesis.


  Endocrine-Disrupting Chemicals Top


Endocrine-disrupting chemicals interacting with androgen receptors

Endocrine-disrupting chemicals based on their interaction with androgen receptors, are classified into agonists and antagonists. Agonists bind to androgen receptors and mimic the biological activity of androgens leading to amplified cellular response. In the pilosebaceous units, androgen receptor agonists induce hyperplasia of the sebaceous gland, excessive sebum production, proliferation and cornification of keratinocytes.[12] Araki et al. were the first investigators who showed that two organic compounds, 2-tert-butyl anthraquinone and benzanthrone which are used in the manufacture of dyes and food package, were weak agonists of rat androgen receptors and their androgenic activity was 1000-10000 times less potent than that of dihydrotestosterone.[13] Relatively, recent studies suggested that brominated flame retardant used in construction materials may activate human androgen receptors with high potency.[14],[15] Furthermore, particularly, important were the results of anin vitro study which identified six commonly used ultraviolet filters (benzophenone-2, isopentyl-4-methoxycinnamate, octyl methoxycinnamate, octocrylene, homosalate and octyl salicylate) acting as human androgen receptor agonists. Interestingly preparation of the cultures with the aforementioned ultraviolet filters and dihydrotestosterone resulted in the inhibition of dihydrotestosterone activity, indicating that ultraviolet filters may act as pure human androgen receptor agonists only in the absence of androgens.[16] Phthalates represent an additional group of chemicals for which there are numerous studies demonstrating their interference with endocrine system. Incubation of human cells with three broadly used phthalates (mono-n-butyl phthalate, dibutyl phthalate and di-2-ethylhexyl-phthalate) induced dose-dependent increase of androgenic activity, whereas the subsequent addition of flutamide reversed the aforementioned effects.[17]

Endocrine-disrupting chemicals acting without binding to androgen receptors

Ongoing research for endocrine-disrupting chemicals has revealed a novel class of chemicals which induce androgenic activity without being androgen receptors agonists. Triclocarban and other structurally similar urea compounds which are used in detergents and personal care products as antibacterial or antifungal agents have been found to amplify the cellular response and transcriptional activity induced by endogenous androgens without actually binding to the androgen receptors. No androgenic effect was observed when cells expressing human androgen receptors were incubated exclusively with triclocarban and neither did triclocarban compete with testosterone for binding to androgen receptors on a competitive binding assay.[18]

Pesticides are another group of endocrine disruptors which induce hormonal abnormalities by inhibiting aromatase activity. Aromatase which is a member of the cytochrome P450 superfamily is a determinant factor for sex hormones' balance because it converts androstenedione and testosterone to estrone and estradiol, respectively. Consequently, inhibition of aromatase activity results in the accumulation of androgens. Seven commonly used pesticides and glyphosate-based herbicides (prochloraz, imazalil, propiconazole, fenarimol, triadimenol, triadimefon and dicofol) were documented to significantly inhibit aromatase activity in human placental microsomes.[19],[20],[21]

Endocrine-disrupting chemicals acting through multiple pathways

Bisphenol A is an endocrine disruptor which has been incriminated in inhibiting aromatase synthesis as shown by the inverse correlation of aromatase mRNA and bisphenol A levels in the culture of rat ovarian granulosa cells.[22]In vitro studies on human cells have shown the inhibitory effect of bisphenol A on aromatase activity which depended not only on the concentration but also on time exposure.[23],[24] Short time incubation (10 min to 6 h) enhanced aromatase activity, whereas long time incubation (18 h) caused dose-dependent reduction. Apart from aromatase, it was suggested that bisphenol A may reduce the activity of other male-specific P450 isoforms which play a crucial role in oxidative metabolism of androgens. Intraperitoneal treatment of rats with bisphenol A led to decreased hydroxylation and excretion of testosterone, resulting in increased levels of free testosterone.[25] Interference of bisphenol A with human sex hormone binding globulin is an additional mechanism leading to increased free testosterone. Bisphenol A was found to displace endogenous androgens from human sex hormone binding globulin binding sites, despite its low binding affinity.[26]

Some studies have demonstrated the androgenic potential of polychlorinated biphenyls which caused dose-dependent stimulation of rat androgen receptors.[27] Consistent with these results, a bioluminescent androgen screening assay showed that polychlorinated biphenyls may increase androgen receptor-mediated transcriptional activity.[28] In anotherin vitro study, very low levels of estradiol were found in the media of a culture of human placental cells treated with polychlorinated biphenyls mixture and dehydroepiandrosterone. The researchers suggested that polychlorinated biphenyls mixture abolished the conversion of dehydroepiandrosterone to estradiol by inhibiting aromatase activity.[29]

Tributyltin remains one of the most significant pollutants of the marine and aquatic environment despite its prohibited use. This endocrine disruptor inhibits aromatase activity as shown by the increased testosterone and decreased 17-β-estradiol levels in male rats treated with tributyltin.[30] The above findings were also confirmed by anin vitro study on human cells.[31] In addition, there are studies showing enhancement of the androgenic response after the incubation of cells with tributyltin and dihydrotestosterone, indicating a presumptive synergistic action.[32] Furthermore, it was suggested that tributyltin may elevate androgen levels by inhibiting the sulfur conjugation of testosterone and its active metabolites, resulting in its limited excretion.[33]


  Discussion Top


Although research in the past years has significantly contributed to better insights into the pathogenesis of acne, there are still many pathways remaining to be elucidated. Persistently high prevalence, increase in chronic forms and poor response to treatment suggest the role of as yet unknown factors in its causation. As previously demonstrated, several endocrine-disrupting chemicals have the potential to increase levels of androgens or cellular response to them; however, not all of them are able to induce acne. Though it has been hypothesized that stimulation of androgen receptors by endocrine-disrupting chemicals may contribute to its pathogenesis, a definite causal relationship between such chemicals and acne is yet to be established. Exposure to these environmental agents may be a determinant factor which in combination with excess sebum production, altered follicular growth, Propionibacterium acnes colonization and inflammation, triggers the initiation and the development of acne.

The potential contribution of endocrine-disrupting chemicals to acne pathogenesis is important due to the widespread use of such chemicals in a huge variety of consumer goods and even children's toys.[34] Due to the high bioaccumulation and low biodegradation rates, endocrine-disrupting chemicals are found to persist in sediment, air, water and animals. It is worth noting that they have been easily detected in both human urine and plasma samples and in breast milk, clearly showing the extent of human exposure.[35],[36] It is still debatable if the prevailing concentrations of endocrine-disrupting chemicals can cause androgenic effects in humans. This dose–response relationship has raised controversies because of the relatively low amounts of endocrine-disrupting chemicals in the environment. In addition, most of the data for endocrine-disrupting chemicals has been derived fromin vitro and animals studies. Since acne is a skin disorder exclusively seen in humans, the effect of such chemicals on acne pathogenesis cannot be studied in animal models. On the other hand, simply extrapolating data from in vitro studies may be not be wise either. Accurate evaluation of the effects of endocrine-disrupting chemicals on pilosebaceous units requires human studies of long-term exposure to low concentrations and to mixtures of such compounds. The above review could serve as a stimulus to conductin vivo human studies or epidemiological researches to assess the role of the environment on acne pathogenesis.


  Conclusion Top


The present article emphasizes the constant interaction of humans with their environment. According to the results ofin vitro studies, endocrine-disrupting chemicals are able to elevate androgen levels and consequently it is suggested that they may also contribute to acne. Due to the absence of clinical studies, it is not currently possible to draw conclusions regarding the importance of this hypothesis, but it might stimulate the design of large-scale studies to obtain an in-depth knowledge of acne.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

 
  References Top

1.
Oberemok SS, Shalita AR. Acne vulgaris, I: Pathogenesis and diagnosis. Cutis 2002;70:101-5.  Back to cited text no. 1
    
2.
Gollnick H, Cunliffe W, Berson D, Dreno B, Finlay A, Leyden JJ, et al. Management of acne: A report from a Global Alliance to Improve Outcomes in Acne. J Am Acad Dermatol 2003;49 1 Suppl: S1-37.  Back to cited text no. 2
    
3.
Bhate K, Williams HC. Epidemiology of acne vulgaris. Br J Dermatol 2013;168:474-85.  Back to cited text no. 3
    
4.
Cordain L, Lindeberg S, Hurtado M, Hill K, Eaton SB, Brand-Miller J. Acne vulgaris: A disease of Western civilization. Arch Dermatol 2002;138:1584-90.  Back to cited text no. 4
    
5.
Lucky AW, Biro FM, Huster GA, Leach AD, Morrison JA, Ratterman J. Acne vulgaris in premenarchal girls. An early sign of puberty associated with rising levels of dehydroepiandrosterone. Arch Dermatol 1994;130:308-14.  Back to cited text no. 5
    
6.
Stewart ME, Downing DT, Cook JS, Hansen JR, Strauss JS. Sebaceous gland activity and serum dehydroepiandrosterone sulfate levels in boys and girls. Arch Dermatol 1992;128:1345-8.  Back to cited text no. 6
    
7.
Lowenstein EJ. Diagnosis and management of the dermatologic manifestations of the polycystic ovary syndrome. Dermatol Ther 2006;19:210-23.  Back to cited text no. 7
    
8.
Hamilton JB, Mestler GE. Effect of orchiectomy and ooephorectomy upon existent and potential acne. J Invest Dermatol 1963;41:249-53.  Back to cited text no. 8
    
9.
Pochi PE, Strauss JS, Mescon H. Sebum secretion and urinary fractional 17-ketosteroid and total 17-hydroxycorticoid excretion in male castrates. J Invest Dermatol 1962;39:475-83.  Back to cited text no. 9
    
10.
Zouboulis CC. Treatment of acne with antiandrogens – An evidence-based review. J Dtsch Dermatol Ges 2003;1:535-46.  Back to cited text no. 10
    
11.
Diamanti-Kandarakis E, Bourguignon JP, Giudice LC, Hauser R, Prins GS, Soto AM, et al. Endocrine-disrupting chemicals: An Endocrine Society scientific statement. Endocr Rev 2009;30:293-342.  Back to cited text no. 11
    
12.
Luccio-Camelo DC, Prins GS. Disruption of androgen receptor signaling in males by environmental chemicals. J Steroid Biochem Mol Biol 2011;127:74-82.  Back to cited text no. 12
    
13.
Araki N, Ohno K, Nakai M, Takeyoshi M, Iida M. Screening for androgen receptor activities in 253 industrial chemicals byin vitro reporter gene assays using AR-EcoScreen cells. Toxicol In Vitro 2005;19:831-42.  Back to cited text no. 13
    
14.
Khalaf H, Larsson A, Berg H, McCrindle R, Arsenault G, Olsson PE. Diastereomers of the brominated flame retardant 1,2-dibromo-4-(1,2 dibromoethyl) cyclohexane induce androgen receptor activation in the hepg2 hepatocellular carcinoma cell line and the lncap prostate cancer cell line. Environ Health Perspect 2009;117:1853-9.  Back to cited text no. 14
    
15.
Larsson A, Eriksson LA, Andersson PL, Ivarson P, Olsson PE. Identification of the brominated flame retardant 1,2-dibromo-4-(1,2-dibromoethyl) cyclohexane as an androgen agonist. J Med Chem 2006;49:7366-72.  Back to cited text no. 15
    
16.
Kunz PY, Fent K. Multiple hormonal activities of UV filters and comparison ofin vivo andin vitro estrogenic activity of ethyl-4-aminobenzoate in fish. Aquat Toxicol 2006;79:305-24.  Back to cited text no. 16
    
17.
Shen O, Du G, Sun H, Wu W, Jiang Y, Song L, et al. Comparison ofin vitro hormone activities of selected phthalates using reporter gene assays. Toxicol Lett 2009;191:9-14.  Back to cited text no. 17
    
18.
Chen J, Ahn KC, Gee NA, Ahmed MI, Duleba AJ, Zhao L, et al. Triclocarban enhances testosterone action: A new type of endocrine disruptor? Endocrinology 2008;149:1173-9.  Back to cited text no. 18
    
19.
Vinggaard AM, Hnida C, Breinholt V, Larsen JC. Screening of selected pesticides for inhibition of CYP19 aromatase activity in vitro. Toxicol In Vitro 2000;14:227-34.  Back to cited text no. 19
    
20.
Andersen HR, Vinggaard AM, Rasmussen TH, Gjermandsen IM, Bonefeld-Jørgensen EC. Effects of currently used pesticides in assays for estrogenicity, androgenicity, and aromatase activity in vitro. Toxicol Appl Pharmacol 2002;179:1-12.  Back to cited text no. 20
    
21.
Gasnier C, Dumont C, Benachour N, Clair E, Chagnon MC, Séralini GE. Glyphosate-based herbicides are toxic and endocrine disruptors in human cell lines. Toxicology 2009;262:184-91.  Back to cited text no. 21
    
22.
Zhou W, Liu J, Liao L, Han S, Liu J. Effect of bisphenol A on steroid hormone production in rat ovarian theca-interstitial and granulosa cells. Mol Cell Endocrinol 2008;283:12-8.  Back to cited text no. 22
    
23.
Nativelle-Serpentini C, Richard S, Séralini GE, Sourdaine P. Aromatase activity modulation by lindane and bisphenol-A in human placental JEG-3 and transfected kidney E293 cells. Toxicol In Vitro 2003;17:413-22.  Back to cited text no. 23
    
24.
Bonefeld-Jørgensen EC, Long M, Hofmeister MV, Vinggaard AM. Endocrine-disrupting potential of bisphenol A, bisphenol A dimethacrylate, 4-n-nonylphenol, and 4-n-octylphenol in vitro: New data and a brief review. Environ Health Perspect 2007;115 Suppl 1:69-76.  Back to cited text no. 24
    
25.
Hanioka N, Jinno H, Nishimura T, Ando M. Suppression of male-specific cytochrome P450 isoforms by bisphenol A in rat liver. Arch Toxicol 1998;72:387-94.  Back to cited text no. 25
    
26.
Déchaud H, Ravard C, Claustrat F, de la Perrière AB, Pugeat M. Xenoestrogen interaction with human sex hormone-binding globulin (hSHBG). Steroids 1999;64:328-34.  Back to cited text no. 26
    
27.
Portigal CL, Cowell SP, Fedoruk MN, Butler CM, Rennie PS, Nelson CC. Polychlorinated biphenyls interfere with androgen-induced transcriptional activation and hormone binding. Toxicol Appl Pharmacol 2002;179:185-94.  Back to cited text no. 27
    
28.
Svobodová K, Placková M, Novotná V, Cajthaml T. Estrogenic and androgenic activity of PCBs, their chlorinated metabolites and other endocrine disruptors estimated with twoin vitro yeast assays. Sci Total Environ 2009;407:5921-5.  Back to cited text no. 28
    
29.
Grabic R, Hansen LG, Ptak A, Crhova S, Gregoraszczuk EL. Differential accumulation of low-chlorinated (Delor 103) and high-chlorinated (Delor 106) biphenyls in human placental tissue and opposite effects on conversion of DHEA to E2. Chemosphere 2006;62:573-80.  Back to cited text no. 29
    
30.
Omura M, Ogata R, Kubo K, Shimasaki Y, Aou S, Oshima Y, et al. Two-generation reproductive toxicity study of tributyltin chloride in male rats. Toxicol Sci 2001;64:224-32.  Back to cited text no. 30
    
31.
Benachour N, Moslemi S, Sipahutar H, Seralini GE. Cytotoxic effects and aromatase inhibition by xenobiotic endocrine disrupters alone and in combination. Toxicol Appl Pharmacol 2007;222:129-40.  Back to cited text no. 31
    
32.
Yamabe Y, Hoshino A, Imura N, Suzuki T, Himeno S. Enhancement of androgen-dependent transcription and cell proliferation by tributyltin and triphenyltin in human prostate cancer cells. Toxicol Appl Pharmacol 2000;169:177-84.  Back to cited text no. 32
    
33.
Ronis MJ, Mason AZ. The metabolism of testosterone by the periwinkle (Littorina littorea)in vitro and in vivo: Effects of tributyltin. Marine Environ Res 1996;42:161-6.  Back to cited text no. 33
    
34.
Schettler T. Human exposure to phthalates via consumer products. Int J Androl 2006;29:134-9.  Back to cited text no. 34
    
35.
Janjua NR, Mogensen B, Andersson AM, Petersen JH, Henriksen M, Skakkebaek NE, et al. Systemic absorption of the sunscreens benzophenone-3, octyl-methoxycinnamate, and 3-(4-methyl-benzylidene) camphor after whole-body topical application and reproductive hormone levels in humans. J Invest Dermatol 2004;123:57-61.  Back to cited text no. 35
    
36.
Schlumpf M, Kypke K, Wittassek M, Angerer J, Mascher H, Mascher D, et al. Exposure patterns of UV filters, fragrances, parabens, phthalates, organochlor pesticides, PBDEs, and PCBs in human milk: Correlation of UV filters with use of cosmetics. Chemosphere 2010;81:1171-83.  Back to cited text no. 36
    




 

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