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Year : 2016  |  Volume : 82  |  Issue : 6  |  Page : 740-743

Recurrent ulcers in the flexures of a 48-year-old woman


1 Department of Dermatology, Venereology and Leprosy, Care Institute of Medical Sciences, Hyderabad, Telangana, India
2 Department of Pathology, Care Institute of Medical Sciences, Hyderabad, Telangana, India

Date of Web Publication18-Jul-2016

Correspondence Address:
Dr. Laxmi Chandravathi Penmetcha
Department of Dermatology, Care Institute of Medical Sciences, Road No. 10, Banjara Hills, Hyderabad - 500 034, Telangana
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0378-6323.186479

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How to cite this article:
Penmetcha LC, Awake P, Fonseca A. Recurrent ulcers in the flexures of a 48-year-old woman. Indian J Dermatol Venereol Leprol 2016;82:740-3

How to cite this URL:
Penmetcha LC, Awake P, Fonseca A. Recurrent ulcers in the flexures of a 48-year-old woman. Indian J Dermatol Venereol Leprol [serial online] 2016 [cited 2019 Oct 16];82:740-3. Available from: http://www.ijdvl.com/text.asp?2016/82/6/740/186479


A 48-year-old woman presented with a 4-year history of recurrent painful erythematous ulcerated lesions in with purulent secretion along with fibrosis and adhesions in her right axilla [Figure 1]a and multiple severe ulcers in both groins disabling the mobility of limbs [Figure 1]b. The remainder of the mucocutaneous examination including hair, nails, teeth and mucosae was normal.
Figure 1: (a) Erythematous ulcers with adhesions in the right axilla. (b) Multiple severe ulcers in both groins

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There were no costitutional symptoms. The patient had diabetes mellitus and hypertension. Systemic examination was normal. Serum biochemistry, lung function tests and, urine osmolality were all within normal limits. Bone marrow biopsy report showed no abnormality. Imaging studies were normal. A skin biopsy specimen was obtained from the lesions.

Histopathological examination revealed a nodular infiltrated lesion in dermis. The overlying epidermis was ulcerated and the dermis showed a lesion composed of ovoid cells with moderate amounts of eosinophilic cytoplasm and an indented reniform nucleus with an admixed cellular inflammatory infiltrate of neutrophils, eosinophils and mast cells [Figure 2]a and [Figure 2]b. On immunohistochemical study, the tumoral cells showed strong cytoplasmic positivity for CD1a and were negative for CD 68 [Figure 3].
Figure 2: (a) Nodular infiltrated lesion in dermis with ulcerated overlying epidermis (H and E, ×10). (b) Ovoid cells with moderate amounts of eosinophilic cytoplasm and an indented reniform nucleus with an admixed cellular inflammatory infiltrate of neutrophils, eosinophils and mast cells (H and E, ×400)

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Figure 3: Immunohistochemical staining is positive for CD1a (immunostain CD1a, ×100)

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  References Top

1.
Pan Z, Sharma S, Sharma P. Primary Langerhans cell histiocytosis of the vulva: Report of a case and brief review of the literature. Indian J Pathol Microbiol 2009;52:65-8.  Back to cited text no. 1
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2.
Nezelof C, Basset F. An hypothesis Langerhans cell histiocytosis: The failure of the immune system to switch from an innate to an adaptive mode. Pediatr Blood Cancer 2004;42:398-400.  Back to cited text no. 2
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3.
Walia SS, Gayer K. An unusual presentation of refractory cutaneous Langerhans cell histiocytosis in an adult. J Drugs Dermatol 2006;5:174-7.  Back to cited text no. 3
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4.
Sander CS, Kaatz M, Elsner P. Successful treatment of cutaneous Langerhans cell histiocytosis with thalidomide. Dermatology 2004;208:149-52.  Back to cited text no. 4
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5.
Kolde G, Schulze P, Sterry W. Mixed response to thalidomide therapy in adults: Two cases of multisystem Langerhans' cell histiocytosis. Acta Derm Venereol 2002;82:384-6.  Back to cited text no. 5
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