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Year : 2016  |  Volume : 82  |  Issue : 5  |  Page : 587--588

Effects of isotretinoin on the thyroid gland and thyroid function tests in acne patients: A preliminary study

1 Department of Dermatology, Faculty of Medicine, Sifa University, Izmir, Turkey
2 Department of Radiology, Faculty of Medicine, Sifa University, Izmir, Turkey
3 Department of Endocrinology, Faculty of Medicine, Sifa University, Izmir, Turkey
4 Department of Biochemistry, Faculty of Medicine, Sifa University, Izmir, Turkey

Correspondence Address:
Dr. Belkiz Uyar
35240, 172/2 Fevzipaşa Bulvarı Basmane, Izmir
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0378-6323.182794

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Background: Isotretinoin is widely used in the treatment of acne. Aims: We investigated the effects of isotretinoin on thyroid function tests and thyroid volume in acne patients. Methods: In this prospective study, a total of 104 acne patients were included. Sixty-six patients were treated with isotretinoin for at least 4 months. Thirty eight patients were included in the control group. The levels of thyroid stimulating hormone, free triiodothyronine, free thyroxine, antithyroglobulin and antithyroid peroxidase antibodies were measured and a thyroid ultrasound was performed in all the subjects before treatment and 4 months after treatment. A “p” value of < 0.05 was considered significant. Results: In the isotretinoin-treated group, thyroid stimulating hormone levels increased significantly during isotretinoin treatment (P = 0.018). Free triiodothyronine, free thyroxine, anti-thyroid peroxidase levels and thyroid volume decreased significantly during treatment (P = 0.016, P= 0.012, P= 0.006, P = 0.020 respectively). Limitations: The major limitation of this study is the lack of follow-up data after the cessation of isotretinoin therapy in acne patients. Conclusion: Patients treated with isotretinoin should be monitored with thyroid function tests.


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Online since 15th March '04
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