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Year : 2016  |  Volume : 82  |  Issue : 4  |  Page : 464-466

Yellowish-white papules in a cobblestone pattern on the neck


1 Department of Dermatology, Hospital Universitario Infanta Leonor, Madrid, Spain
2 Department of Histopathology, Hospital Universitario Infanta Leonor, Madrid, Spain

Date of Web Publication6-Jun-2016

Correspondence Address:
Dr. Elena Conde-Montero
Department of Dermatology, Hospital Universitario Infanta Leonor, Madrid
Spain
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0378-6323.181504

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How to cite this article:
Conde-Montero E, Chavarría Mur E, Rivera García T, de la Cueva Dobao P. Yellowish-white papules in a cobblestone pattern on the neck. Indian J Dermatol Venereol Leprol 2016;82:464-6

How to cite this URL:
Conde-Montero E, Chavarría Mur E, Rivera García T, de la Cueva Dobao P. Yellowish-white papules in a cobblestone pattern on the neck. Indian J Dermatol Venereol Leprol [serial online] 2016 [cited 2019 Sep 19];82:464-6. Available from: http://www.ijdvl.com/text.asp?2016/82/4/464/181504


A 65-year-old woman with an unremarkable medical history was referred to our department with a 2-year history of multiple pruritic lesions on the lateral and posterior parts of her neck. She denied any history of preceding trauma or prolonged sun exposure at the affected sites. None of her family members had similar skin lesions. She had no history of renal disease or intake of drugs like D-penicillamine. Physical examination revealed multiple, yellowish-white, 2 mm, non-follicular papules coalescing to form cobblestone-like plaques on her neck [Figure 1]. No other sites were involved. A representative lesion was biopsied and no histological abnormalities were found with routine hematoxilyn-eosin staining [Figure 2]. Special staining with acid orcein demonstrated loss of elastic tissue in the papillary dermis and an anomalous distribution and morphology of elastic fibers in the reticular dermis [Figure 3]. Blood tests, cardiovascular and ophthalmological examinations were completely normal.
Figure 1: Multiple yellowish-white non-follicular papules forming cobblestone-like plaques on the neck

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Figure 2: Panoramic view showing apparently normal skin (H and E ×20)

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Figure 3: Orcein stain reveals loss of elastic tissue in the papillary dermis with an anomalous distribution and morphology of elastic fibers in the reticular dermis (×400)

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  References Top

1.
Rongioletti F, Rebora A. Pseudoxanthoma elasticum-like papillary dermal elastolysis. J Am Acad Dermatol 1992;26:648-50.  Back to cited text no. 1
    
2.
Vázquez-Osorio I, Rosón E, Suárez-Peñaranda JM, Vázquez-Veiga H. Pseudoxanthoma elasticum-like papillary dermal elastolysis. Actas Dermosifiliogr 2015;106:333-6.  Back to cited text no. 2
    
3.
Rongioletti F, Izakovic J, Romanelli P, Lanuti E, Miteva M. Pseudoxanthoma elasticum-like papillary dermal elastolysis: A large case series with clinicopathological correlation. J Am Acad Dermatol 2012;67:128-35.  Back to cited text no. 3
    
4.
Revelles JM, Machan S, Pielasinski U, Camacho D, Vallés L, Santonja C, et al. Pseudoxanthoma elasticum-like papillary dermal elastolysis: Immunohistochemical study using elastic fiber cross-reactivity with an antibody against amyloid P component. Am J Dermatopathol 2012;34:637-43.  Back to cited text no. 4
    


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