|Year : 2016 | Volume
| Issue : 1 | Page : 109-111
Solitary asymptomatic nodule on the leg
Ana Almodovar-Real1, José Aneiros-Fernandez2, Miguel A Diaz-Martinez1, Ramón Naranjo-Sintes1
1 Department of Dermatology, San Cecilio University Hospital, Granada, Spain
2 Department of Pathology, San Cecilio University Hospital, Granada, Spain
|Date of Web Publication||31-Dec-2015|
Department of Dermatology, San Cecilio University Hospital, Avenida Doctor Olóriz 16, 18012 Granada
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Almodovar-Real A, Aneiros-Fernandez J, Diaz-Martinez MA, Naranjo-Sintes R. Solitary asymptomatic nodule on the leg. Indian J Dermatol Venereol Leprol 2016;82:109-11
|How to cite this URL:|
Almodovar-Real A, Aneiros-Fernandez J, Diaz-Martinez MA, Naranjo-Sintes R. Solitary asymptomatic nodule on the leg. Indian J Dermatol Venereol Leprol [serial online] 2016 [cited 2020 Jan 26];82:109-11. Available from: http://www.ijdvl.com/text.asp?2016/82/1/109/168940
A 58-year-old man presented with an asymptomatic skin nodule on the left leg for several months. Physical examination showed a well-defined, erythematous nodule (2 cm × 1.5 cm) with a lobulated surface [Figure 1]. Differential diagnoses of squamous cell carcinoma, basal cell carcinoma and cutaneous lymphoma were considered. An excisional biopsy was performed. Histopathology showed pseudoepitheliomatous hyperplasia [Figure 2]. There was a dense, irregular, lymphoid infiltrate with admixture of neutrophils, eosinophils and large, atypical Reed-Sternberg-like cells in the dermis [Figure 3]. Immunohistochemical analysis revealed strong positivity for CD30 [Figure 4]a. Tumor cells were also positive for the cytotoxic marker T-cell intracellular antigen-1 [Figure 4]b, CD3, CD7 and CD4 [Figure 4]c. On the other hand, AE1-AE3, CD8, CD56, CD20, ALK-1, CD5, CD15 and CD25 were all negative. Routine investigations and positron emission tomography-computed tomography study were normal. There was no recurrence after 1 year of follow-up.
|Figure 3: Dense infiltrates of atypical lymphocytes in dermis; large and atypical Reed–Sternberg-like cells (H and E, ×200)|
Click here to view
|Figures 4: Neoplastic cells positive for (a) CD30 (×100), (b) cytotoxic marker T-cell intracellular antigen-1 (×100) and (c) CD4 (×100)|
Click here to view
| What Is Your Diagnosis?|| |
| References|| |
Szpor J, Dyduch G, Galazka K, Bahyrycz J, Stój A, Tomaszewska R. Primary cutaneous CD30+lymphoproliferative disorder – A 10-year follow-up. A case report and differential diagnosis. Pol J Pathol 2009;60:43-8.
Ralfkiaer E, Willemze R, Paulli M, Kadin ME. Primary cutaneous CD30-positive T-cell lymphoproliferative disorders. In: Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, et al
., editors. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4th
ed. Lyon: IARC; 2008. p. 300-1.
Quintanilla-Martinez L, Jansen PM, Kinney MC, Swerdlow SH, Willemze R. Non-mycosis fungoides cutaneous T-cell lymphomas: Report of the 2011 Society for Hematopathology/European Association for Haematopathology workshop. Am J Clin Pathol 2013;139:491-514.
Querfeld C, Kuzel TM, Guitart J, Rosen ST. Primary cutaneous CD30+ lymphoproliferative disorders: New insights into biology and therapy. Oncology (Williston Park) 2007;21:689-96.
Kadin ME. Primary cutaneous CD30-positive T-cell lymphoproliferative disorders. In: Jaffe ES, editor. Hematopathology: Expert Consult. 1st
ed. Philadelphia, PA: Saunders/Elsevier; 2011. p. 604-16.
[Figure 1], [Figure 2], [Figure 3], [Figure 4]