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 CASE REPORT
Year : 2014  |  Volume : 80  |  Issue : 6  |  Page : 526--529

Peripheral T-cell lymphoma at the injection site of influenza vaccination


1 Department of Dermatology, Changhai Hospital, Second Military Medical University, Shanghai, China
2 Department of Dermatology, Outpatient Clinic, Changhai Hospital, Second Military Medical University, Shanghai, China
3 Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai, China

Correspondence Address:
Jun Gu
Department of Dermatology, Changhai Hospital, Second Military Medical University, Shanghai
China
Miao-xia He
Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai
China
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Source of Support: This work was supported by grants from Natural Science Foundation of Shanghai (No. 11ZR14474000), Special Fund for Military Medicine of SMMU (2012), Conflict of Interest: None


DOI: 10.4103/0378-6323.144165

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Pseudolymphomas or B-cell lymphoma at the vaccination site have been reported by several authors. However, onset of cutaneous T-cell lymphoma with cytotoxic features is a rare complication of vaccination. We report a 27-year-old man who developed a nodule and ulcer that arose at the site of injection of influenza vaccine. The neoplastic cells reacted positively for CD56, CD3, CD2, perforin, and granzyme B, but negatively for CD4, CD8, CD10, CD19, CD30, CD34, CD79, and betaF1. Molecular studies showed T-cell receptor γ (TCR-γ) chain monoclonal rearrangement. A diagnosis of peripheral T-cell lymphoma, not otherwise specified (NOS) was established. The patient had high fever, progressive liver dysfunction and a rapid fatal evolution.






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