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 ORIGINAL ARTICLE
Year : 2014  |  Volume : 80  |  Issue : 4  |  Page : 291--295

A new occlusive patch test system comparable to IQ and Finn chambers


1 Department of Clinical Research, CLAIMS Pvt. Ltd., Mumbai, Maharashtra, India
2 Department of Dermatology, CLAIMS Pvt. Ltd., Mumbai, Maharashtra, India
3 Department of Pharmacy, CLAIMS Pvt. Ltd., Mumbai, Maharashtra, India

Correspondence Address:
Shaziya Z Sajun Merchant
CLAIMS Pvt. Ltd., 4th Floor, B Wing, Modi House, C 10, Dalia Industrial Estate, New Link Road, Andheri (W), Mumbai - 400 058, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0378-6323.136830

Clinical trial registration CTRI/2011/03/001652

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Background: A good patch test system should have good adhesion and contact, and minimal leakage; Finn and IQ patch test system have these properties but are expensive. Aims: To develop a new cost-effective occlusive patch test system that had good contact with the skin and was non-irritant. Methods: The system (designated Chamber X) was fabricated using a semi-permeable tape and a flexible virgin plastic chamber. Chamber X was developed by (i) selecting adhesive tape based on its non irritancy and adhesive potential (ii) testing plastic chamber material for its skin irritancy (iii) testing the assembled system against Finn, IQ and locally available chambers for irritancy, contact, leakage and occlusivity. Results: Chamber X showed better occlusion than IQ, Finn and locally available chambers and was comparable to, (P > 0.05) IQ and Finn in terms of irritancy, contact and leakage. Conclusions: The results demonstrate that the Chamber X offers a cost effective patch test system comparable to IQ and Finn chambers in terms of safety, adhesion, leakage and occlusivity.






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Online since 15th March '04
Published by Wolters Kluwer - Medknow