IADVL
Indexed with PubMed and Science Citation Index (E) 
 
Users online: 1906 
     Home | Feedback | Login 
About Current Issue Archive Ahead of print Search Instructions Online Submission Subscribe What's New Contact  
  Navigate here 
  Search
 
  
 Resource links
   Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
   Article in PDF (1,883 KB)
   Citation Manager
   Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
* Registration required (free)  

 
  In this article
   References
   Article Figures

 Article Access Statistics
    Viewed2275    
    Printed37    
    Emailed1    
    PDF Downloaded112    
    Comments [Add]    
    Cited by others 1    

Recommend this journal

 


 
 Table of Contents    
LETTER TO EDITOR
Year : 2013  |  Volume : 79  |  Issue : 5  |  Page : 711-713

Verrucous growth arising over hypertrophic lichen planus


1 Department of Dermatology, Father Muller Medical College, Kankanady, Mangalore, India
2 Department of Pathology, Father Muller Medical College, Kankanady, Mangalore, India

Date of Web Publication21-Aug-2013

Correspondence Address:
Ramesh M Bhat
Dermatology, Venereology and Leprosy, Father Muller Medical College, Kankanady, Mangalore - 575 002
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0378-6323.116748

Rights and Permissions



How to cite this article:
Bhat RM, Chathra N, Dandekeri S, Devaraju S. Verrucous growth arising over hypertrophic lichen planus. Indian J Dermatol Venereol Leprol 2013;79:711-3

How to cite this URL:
Bhat RM, Chathra N, Dandekeri S, Devaraju S. Verrucous growth arising over hypertrophic lichen planus. Indian J Dermatol Venereol Leprol [serial online] 2013 [cited 2019 Nov 17];79:711-3. Available from: http://www.ijdvl.com/text.asp?2013/79/5/711/116748


Sir,

A 57-year-old male presented to our dermatology out-patient department with complaints of raised, verrucous growth of 2 years duration over his right leg. Six months prior to the appearance of this lesion, patient had itchy voilaceous lesions over both his legs, which were diagnosed as hypertrophic lichen planus (HLP) and treated accordingly. He reported that the present growth appeared over pre-existing violaceous lesion and was initially pea-sized. The lesion enlarged and attained its present size within the next 3 months. Occasionally, the lesion was associated with pain and bleeding. He did not give any history of trauma or contact with an irritant prior to the appearance of the lesion. There was no history of photosensitivity, loss of weight or any other systemic symptoms.

Cutaneous examination revealed a solitary, well-circumscribed, exophytic growth measuring 6 cm × 6 cm, seen over middle one-third of right shin. Its surface was papillated with a few hemorrhagic crusts. There was no local tenderness, easy friability or bleeding on manipulation. The lesion was mobile and without induration. The surrounding skin showed hyper-pigmented, scaly plaques interspersed with de-pigmented macules [Figure 1]. Violaceous reticulated plaques were seen over buccal mucosa. A single lymph node of the right inguinal group was enlarged, mobile and non-tender. With these clinical features, we speculated the lesion to be squamous cell carcinoma (SCC) arising over HLP.
Figure 1: Solitary hyperkeratotic growth seen over the anterior surface of the right leg. A few lichen planus lesions are seen surrounding the growth. Ulcerated area is the site of biopsy

Click here to view


Histopathology of a wedge biopsy specimen from the lesion showed downward proliferation of the epidermis, numerous keratin horns and chronic inflammatory infiltrate in the dermis. A large irregularly shaped crater filled with keratin typical of keratoacanthoma was seen [Figure 2]a. Also, seen were dyskeratotic cells with keratinization giving the tumor islands a glassy appearance [Figure 2]b. In view of these findings and the absence of deeper invasion, a histopathological diagnosis of giant keratoacanthoma was made by the dermatopathologist.
Figure 2: (a) A central, keratin-filled crater with irregular epidermal proliferations extending both upward and downward from the base of the crater (H and E, ×10), (b) Dyskeratotic cells with keratinization giving the tumor islands a glassy appearance (H and E, ×40)

Click here to view


Patient then underwent wide local excision plus split thickness skin grafting, histopathological examination of the excised specimen confirmed the diagnosis of giant keratoacanthoma. On follow-up for 1 year there was no recurrence of the lesion.

HLP is a subacute or chronic variant of lichen planus characterized by hypertrophic or warty lesions, most often found on the pretibial area of the lower limbs. [1] Neoplastic transformation in cutaneous LP is very rare, although the incidence of cancer in oral LP is about 1.3%. [2] The underlying mechanism of this malignant conversion is not exactly known but speculatively, chronic inflammatory processes show an overdrive of growth factors that constantly stimulate epithelial cell proliferation into neoplastic conditions. The majority of reported neoplasms have been histologically well-differentiated SCCs. Two cases of keratoacanthoma, both occurring on the lower legs in association with HLP have been reported.

Keratoacanthomas are fast-growing, solitary, cutaneous neoplasms that usually show spontaneous regression. The most common locations include the face, forearms, and hands; its peak incidence is usually in the fifth decade. Clinically, lesions larger than 20-30 mm are classified as giant keratoacanthomas and they exhibit more aggressive and infiltrative behavior.

A major challenge in dealing with these neoplasms is the difficulty of clinically and histologically differentiating them from SCC. [3] Histopathology of a fully developed lesion shows, in its center a large, irregularly shaped, keratin filled crater with the epidermis extending like a buttress over the sides. Irregular epidermal proliferations extend downward from the base of the crater into the dermis but do not extend below the level of the sweat glands, in contrast to SCC. [4]

These tumors may have an unpredictable and aggressive course; some may spontaneously regress while others may behave like invasive SCC.

Therapeutic modalities for keratoacanthomas include surgical excision, intralesional corticosteroids, topical and intralesional 5-fluorouracil, systemic retinoids, podophyllin, radiation therapy interferon and methothrexate. [5] Most investigators are of the opinion that each case merits a thorough investigation, in accordance with which treatment has to be given. Giant keratoacanthoma arising over HLP is a rare occurrence, nevertheless, to a clinician knowledge about this entity is essential as it demands prompt intervention.

 
  References Top

1.Sigurgeirsson B, Lindelöf B. Lichen planus and malignancy. An epidemiologic study of 2071 patients and a review of the literature. Arch Dermatol 1991;127:1684-8.  Back to cited text no. 1
    
2.Katz RW, Brahim JS, Travis WD. Oral squamous cell carcinoma arising in a patient with long-standing lichen planus. A case report. Oral Surg Oral Med Oral Pathol 1990;70:282-5.  Back to cited text no. 2
[PUBMED]    
3.Giesecke LM, Reid CM, James CL, Huilgol SC. Giant keratoacanthoma arising in hypertrophic lichen planus. Australas J Dermatol 2003;44:267-9.  Back to cited text no. 3
[PUBMED]    
4.Schwartz RA. Keratoacanthoma: A clinico-pathologic enigma. Dermatol Surg 2004;30:326-33.  Back to cited text no. 4
[PUBMED]    
5.Garcia-Zuazaga J, Ke M, Lee P. Giant keratoacanthoma of the upper extremity treated with mohs micrographic surgery: A case report and review of current treatment modalities. J Clin Aesthet Dermatol 2009;2:22-5.  Back to cited text no. 5
[PUBMED]    


    Figures

  [Figure 1], [Figure 2]

This article has been cited by
1 Squamous Cell Carcinoma Arising in Hypertrophic Lichen Planus
Thomas J. Knackstedt,Lindsey K. Collins,Zhongze Li,Shaofeng Yan,Faramarz H. Samie
Dermatologic Surgery. 2015; 41(12): 1411
[Pubmed] | [DOI]



 

Top
Print this article  Email this article

    

Online since 15th March '04
Published by Wolters Kluwer - Medknow