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Year : 2013  |  Volume : 79  |  Issue : 3  |  Page : 291--299

Role of insulin resistance and diet in acne

Department of Dermatology and STD, JIPMER, Pondicherry, India

Correspondence Address:
Rashmi Kumari
Department of Dermatology and STD, JIPMER, Pondicherry - 605 006
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0378-6323.110753

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There is increasing evidence in support of the interplay of growth hormone (GH), insulin, and insulin-like growth factor-1 (IGF-1) signaling during puberty, which have a causal role in pathogenesis of acne by influencing adrenal and gonadal androgen metabolism. Milk consumption and hyperglycemic diets can induce insulin and IGF-1-mediated PI3K ⁄ Akt-activation inducing sebaceous lipogenesis, sebocyte, and keratinocyte proliferation, which can aggravate acne. Occurence of acne as part of various syndromes also provides evidence in favor of correlation between IGF-1 and acne.


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Online since 15th March '04
Published by Wolters Kluwer - Medknow