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 ORIGINAL ARTICLE
Year : 2013  |  Volume : 79  |  Issue : 1  |  Page : 77--82

Efficacy of red light alone and methyl-aminolaevulinate-photodynamic therapy for the treatment of mild and moderate facial acne


1 Department of Medical Specialties, Facultad de Medicina, Universidad de La Frontera, Temuco, Chile
2 Department of Public Health, Facultad de Medicina, Universidad de La Frontera, Temuco, Chile, Clinical Epidemiology Research and Training Center (CERTC), Public Health Doctoral Student, Universidad de Chile, Santiago, Chile
3 Department of Anatomic Pathology, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile
4 Department of Dermatology, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile

Correspondence Address:
Fabiola Schafer
Department of Medical Specialties, Facultad de Medicina, Universidad de La Frontera, Claro Solar St, Temuco
Chile
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0378-6323.104673

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Background: Photodynamic therapy (PDT) has been shown to be an effective alternative for acne. However, there is little information comparing the efficacy of red light alone and methyl aminolaevulinate (MAL)-PDT. Aims: To compare the efficacy and tolerability of red light alone and MAL-PDT in patients with mild to moderate facial acne. Methods: Thirty six patients with mild to moderate acne were enrolled. Eighteen patients recieved MAL-PDT and 18 received red light alone in two sessions, 2 weeks apart. Acne grade and lesion counts were assessed by blinded evaluators at baseline, 2, 4 and 10 weeks. Results: At week 2, clinical improvement from acne grade II-IV to 0-I was observed in 82.3% of MAL-PDT group and 14.2% of red light alone group. Red light alone group had a gradual clinical improvement over time with a 77% response at week 10. In contrast, MAL-PDT group had a rapid clinical improvement with total response at week 10. Both treatments were significantly effective for improving acne lesions. However, MAL-PDT group had a greater response (P < 0.001). Histologically, decreased amounts of sebocytes and lipids along with atrophic sebaceous glands were observed after MAL-PDT. Conclusion: MAL-PDT has a quicker onset of action with a higher response than red light alone. MAL-PDT may induce a reduction in the size of the sebaceous glands and then long-term acne remission.






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