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 RESIDENTS PAGE
Year : 2013  |  Volume : 79  |  Issue : 1  |  Page : 120--126

Acantholysis revisited: Back to basics


Department of Dermatology, PGIMER, Chandigarh, India

Correspondence Address:
M Sendhil Kumaran
Department of Dermatology, Venerology and Leprology, PGIMER, Chandigarh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0378-6323.104688

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Acantholysis means loss of coherence between epidermal cells due to the breakdown of intercellular bridges. It is an important pathogenetic mechanism underlying various bullous disorders, particularly the pemphigus group, as well as many non-blistering disorders. Although a well-known concept, the student often has to refer to many sources to comprehend acantholysis completely. Thorough knowledge of this topic helps in clinching many diagnoses. The etiopathogenesis, classification, clinical signs, and laboratory demonstration of acantholysis are discussed in detail to help students build clear concepts. We have focused on various distinguishing points in different disorders for an easy grasp of the topic.






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Online since 15th March '04
Published by Wolters Kluwer - Medknow