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 ORIGINAL ARTICLE
Year : 2012  |  Volume : 78  |  Issue : 5  |  Page : 620--624

Subungual hyperkeratosis nail biopsy: A better diagnostic tool for onychomycosis


1 Department of Skin and V.D., T.N.M.C. Medical College and B.Y.L. Nair Hospital, Mumbai, India
2 Department of Microbiology, T.N.M.C. Medical College and B.Y.L. Nair Hospital, Mumbai, India

Correspondence Address:
Chitra S Nayak
Department of Skin and V.D, T.N.M.C. Medical College and, B. Y. L. Nair Charitable Hospital, Dr. A. L. Nair road, Mumbai - 400 008
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0378-6323.100579

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Background: Onychomycosis is one of the most common nail disorders. Mycological examination by potassium hydroxide (KOH) mount and fungal culture is the most commonly used diagnostic method. However, it is associated with a low sensitivity. Aims: To evaluate the technique of subungual hyperkeratosis nail biopsy in diagnosing onychomycosis in HIV-infected and immunocompetent adults and compare it with mycological examination. Methods: 34 HIV-positive patients who presented clinically with onychomycosis were recruited in the study from the beginning. There was no screening done for patients with onychomycosis. This has been clarified in manuscript under the heading of methods. Results: All the fungal cultures yielded dermatophytes correlating with the biopsy findings. Only hyphal form of fungus was detected in KOH examination, indicating it was not a contaminant. Clinical types of onychomycosis are stated in discussion. Conclusions: PAS stain of subungual hyperkeratosis nail biopsy was the most sensitive in the diagnosis of onychomycosis in both HIV-infected and non-infected groups.






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Online since 15th March '04
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