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 SYMPOSIUM - VITILIGO
Year : 2012  |  Volume : 78  |  Issue : 1  |  Page : 24--29

On the pathophysiology of vitiligo: Possible treatment options


1 Department of Dermatology, University of Cincinnati, Cincinnati, Ohio, USA
2 Cutaneous Physiopathology and CIRM San Gallicano Dermatologic Institute-IFO, Rome, Italy

Correspondence Address:
Mauro Picardo
Cutaneous Physiopathology and CIRM, San Gallicano Dermatologic Institute-IFO, via Elio Chianesi, 53, 00100 Rome
Italy
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0378-6323.90943

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Vitiligo is an acquired depigmenting disorder usually classified as non-segmental and segmental types with a higher incidence of the non-segmental ones. The cause of non-segmental vitiligo is still unknown. Currently, it is a dogma that there are several genes affecting the immune system and the pigment system that predisposes someone to develop vitiligo. A precipitating factor must then ellicit an interaction between the immune system and the melanocyte, resulting in destruction of the melanocyte population in discrete areas of the skin. Starting from the overlapping but distinct pathomechanisms, treatment should be finalized to the cellular targets and possibly related to the disease phase.






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Online since 15th March '04
Published by Wolters Kluwer - Medknow