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 CASE REPORT
Year : 2011  |  Volume : 77  |  Issue : 5  |  Page : 594--596

Multiple isolated cutaneous plexiform schwannomas


Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Correspondence Address:
Enas A. S. Attia
Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Ain Shams University, Cairo, PO: 11566
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0378-6323.84068

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Plexiform schwannoma is a rare neurogenic tumor, arising from skin and subcutaneous tissue. The presence of multiple schwannomas suggests a possible association with neurofibromatosis type 2 (NF2). A 50-year old male patient presented with multiple papulo-nodular cutaneous lesions on both arms and forearms. Histopathological examination revealed a dermal multinodular pattern of well-circumscribed masses of closely packed cells, with peripheral myxoid tissue, well-encapsulated in a thin collagenous capsule. S-100 immunohistochemical staining was diffusely and strongly positive. Neuron-specific enolase was positive, confirming a neural tissue tumor. An audiogram and Magnetic Resonance Imaging (MRI) of cerebro-pontine angle showed no detected abnormality, excluding acoustic neuroma. Thus, we present a case of multiple bilateral isolated cutaneous plexiform schwannomas, not associated with NF2. Multiple plexiform schwannomas is a very rare entity, distinct from neurofibromatosis (NF), and being confined to the dermis is even more rarely reported.






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Online since 15th March '04
Published by Wolters Kluwer - Medknow