IADVL
Indexed with PubMed and Science Citation Index (E) 
 
Users online: 108 
     Home | Feedback | Login 
About Current Issue Archive Ahead of print Search Instructions Online Submission Subscribe What's New Contact  
  NAVIGATE Here 
    Next article
    Previous article
    Table of Contents

 RESOURCE Links
    Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
  Related articles
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed3037    
    Printed46    
    Emailed2    
    PDF Downloaded55    
    Comments [Add]    

Recommend this journal

 

 CASE REPORT
Year : 2011  |  Volume : 77  |  Issue : 3  |  Page : 314--317

Primary cutaneous follicle center lymphoma in the setting of chronic lymphocytic leukemia


1 Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts 02118,
2 Dermatopathology Section, Boston University School of Medicine, Boston, Massachusetts 02118,

Correspondence Address:
M Mahalingam
609 Albany Street, J-301, Dermatopathology section, Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts 02118

Login to access the Email id


DOI: 10.4103/0378-6323.79702

PMID: 21508570

Get Permissions

Primary cutaneous malignancies arising in association with chronic lymphocytic leukemia (CLL) are notable for their atypical clinical and histological presentation. We report a 69-year-old man with a 17-year history of CLL who presented for evaluation of a well-defined red to violaceous nodule with a central depressed scar on the left lower extremity. Microscopic examination of a punch biopsy revealed an infiltrate of predominantly small lymphocytes with scattered large, atypical epithelioid cells. Immunohistochemical stains revealed diffuse positive staining of the lesional cells with CD20+ and bcl-6+ and focal positive staining with bcl-2+ (negative CD10 and CD23), findings which, in conjunction with the histology, were most compatible with a diagnosis of primary cutaneous follicle center lymphoma (PCFCL). A review of the clinical charts revealed several prior biopsies with varied diagnoses. In light of the most recent biopsy findings, all previous biopsies were re-reviewed and interpreted as PCFCL arising in the setting of CLL. Features contributing to the diagnostic conundrum in this case included an atypical clinical and histological presentation, lack of pertinent clinical history and multiple presentations at different institutions.






[FULL TEXT] [PDF]*


        
Print this article     Email this article

Online since 15th March '04
Published by Medknow