IADVL
Indexed with PubMed and Science Citation Index (E) 
 
Users online: 118 
     Home | Feedback | Login 
About Current Issue Archive Ahead of print Search Instructions Online Submission Subscribe What's New Contact  
  NAVIGATE Here 
    Next article
    Previous article
    Table of Contents

 RESOURCE Links
    Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
  Related articles
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed4154    
    Printed99    
    Emailed4    
    PDF Downloaded129    
    Comments [Add]    

Recommend this journal

 

 ORIGINAL ARTICLE
Year : 2011  |  Volume : 77  |  Issue : 3  |  Page : 288--293

Evaluation of hypothalamic-pituitary-adrenal axis in patients with atopic dermatitis


1 Department of Dermatology, Venerology and Leprology , Post Graduate Institute of Medical Education and Research, Chandigarh, India
2 Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India

Correspondence Address:
A J Kanwar
Department of Dermatology, Venerology and Leprology, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh-160 012
India
Login to access the Email id


DOI: 10.4103/0378-6323.79697

PMID: 21508566

Get Permissions

Background: Most of the research on atopic dermatitis (AD) has focused on the pathophysiological role of the immune system in AD, and the role of endocrine signals in the pathology of AD has not been explored. Current research has shown a link between the neuroendocrine and immune functions. Aim: The aim was to measure the serum basal cortisol levels and cortisol levels following a low-dose ACTH stimulation test in patients with AD before and after treatment with corticosteroids. Methods: Three groups of patients with AD were evaluated: mild, moderate, and severe. Basal cortisol levels following an ACTH stimulation test were measured before and after treatment with topical steroids when an improvement in the disease activity by 75% as determined by the SCORAD index was observed. Results: Eighteen patients of the severe group at baseline showed an impaired hypothalamic-pituitary-adrenal (HPA) axis with cortisol levels <250 nmol/l during their first visit. A total of 13 of 18 patients regained their HPA axis activity when the baseline cortisol was measured after using topical corticosteroids which resulted in 75% improvement in the disease activity. Conclusions: The disease activity rather than the use of topical costicosteroids is responsible for the low basal levels in patients with severe AD.






[FULL TEXT] [PDF]*


        
Print this article     Email this article

Online since 15th March '04
Published by Medknow