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LETTER TO THE EDITOR
Year : 2010  |  Volume : 76  |  Issue : 3  |  Page : 291-293

Dupuytren's disease


Department of Plastic Surgery, NMC Specialty Hospital, Dubai, United Arab Emirates

Date of Web Publication4-May-2010

Correspondence Address:
Sanjay Saraf
Department of Plastic Surgery, NMC Specialty Hospital,Dubai
United Arab Emirates
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0378-6323.62985

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How to cite this article:
Saraf S. Dupuytren's disease. Indian J Dermatol Venereol Leprol 2010;76:291-3

How to cite this URL:
Saraf S. Dupuytren's disease. Indian J Dermatol Venereol Leprol [serial online] 2010 [cited 2020 Mar 31];76:291-3. Available from: http://www.ijdvl.com/text.asp?2010/76/3/291/62985


Sir,

Dupuytren's disease is a fibro-proliferative disorder of unknown etiology, often leading to disabling contractures of the hand. We report a case of Dupuytren's contracture with review of etio-pathology, clinical presentation and management.

A 34-year-old Asian manual laborer presented with progressively worsening contracture of seven years duration involving right ring finger, lately affecting his job. There was no history suggestive of trauma, burns and collagen vascular disease. There was no familial history, no history of diabetes, epilepsy, alcohol consumption and smoking. Physical examination revealed thickening of right palmar aponeurosis with contracture of the finger. There was no detectable joint swelling, tenderness or knuckle pads. Routine laboratory investigations showed no abnormality. The X-ray of the hand was suggestive of flexion deformity of the ring finger with well preserved joint space. In view of significant morbidity; surgical intervention with limited regional fasciectomy technique was done with satisfactory result [Figure 1],[Figure 2],[Figure 3],[Figure 4].

Dupuytren's disease is a disorder of the connective tissue primarily affecting the palmar and digital fascia often leading to disabling contractures of the metacarpophalangeal (MCP) and proximal interphangeal (PIP) joints of the hand.

The condition was first introduced in 1777 by Henry Cline into the medical literature, however, Dupuytren's contracture is named after a French anatomist and surgeon Baron Guillaume Dupuytren who described the condition in detail in 1834. [1],[2]

The etiology of Dupuytren's disease is still unknown. Genetics probably plays an important role and alcoholism, diabetes mellitus, epilepsy and HIV are considered to be significant risk factors for development of this disabling condition. There is a reported positive family history, which provides strong evidence for a genetic influence with many studies suggesting an autosomal dominant pattern of inheritance with variable penetrance. [3],[4] Studies have shown that persons of any race can be affected. [5]

Dupuytren's disease usually has bilateral involvement, however, in unilateral cases, the right side is affected more often than the left. The ring finger is usually affected first, followed by the little finger, and then the middle finger. The disease is six to 10 times more frequent in males than in females.

The progression of the disease occurs in stages. Initially in proliferative stage, nodules develop in the palmar fascia which are known to be the pathognomonic lesion of Dupuytren's contracture and are composed of fibroblasts and type III collagen. With further progression of disease the nodules become a thickened fibrous cord underneath the skin which later thickens and shortens in the active contractile, or involutional stage leading to the development of contractures. [6] The basic pathophysiology of Dupuytren's contracture remains myofibroblast proliferation with increased water levels, type III collagen, chondroitin sulfate, reducible cross-linkages fibroblast proliferation and collagen deposition. The exact cause of uncontrolled proliferation remains unknown, however, many studies have implicated increased expression of growth factors, including basic fibroblast growth factor, platelet-derived growth factor, and transforming growth factor-beta for these changes. [7],[8]

The management of Dupuytren's remains challenging and needs to be individualized. Various medical and surgical modalities have been described depending upon the severity of the symptoms. Usually, asymptomatic cases are better managed with conservative management, while symptomatic disabling cases are indications for surgery.

The non-surgical approach includes splinting, skeletal traction, steroids, calcium channel blockers, dimethylsulfoxide, vitamin E, allopurinol, ultrasound, laser therapy, radiation, Vitamin E and collagenolytic fasciotomy. However, they have not been proven to be of long-term value unless combined with surgical treatment. [9] Steroids do not stop progression of the disease but are often effective in reducing symptoms. A study showed that injections with triamcinolone acetonide (Kenalog), monthly, for up to five months, or every six weeks for up to three injections, followed by a six-month respite lead to significant disease regression. [10]

The role of IFN (interferon) alpha and gamma is also being evaluated and some preliminary studies have found encouraging results. [11],[12] Needle fasciotomy is a quick minimally invasive procedure with no down time. However the chances of recurrence are high and are not effective in treating severe Dupuytren's contracture.

Surgically, excision or incision of the diseased fascia remains the cornerstone of the treatment. The presence of palmar nodule and cord in early stage are not necessarily indications for surgery. A MCP joint contracture and PIP joint contracture of 30 degrees or more is considered to be an indication for surgery. [13] Fasciectomy is the most preferred procedure. The various types of fasciectomy operations described are open fasciectomy (radical), dermofasciectomy and regional fasciectomy. [14] Regional (Selective/Limited) fasciectomy involves excising only grossly involved fascia and is one of the most commonly employed surgical technique with low morbidity and low recurrence rates. However, none of the treatment modalities cure the disease. They only help in preventing further progression of the disease. In near future, further medical advances in genetic engineering might help in stopping or reversing the progression of the disease at cellular level and the ongoing research will form the foundation for future clinical interventions.

 
  References Top

1.Dupuytren BG. Permanent retraction of the fingers, produced by an affection of the palmar fascia. Lancet 1834;2:222-5.   Back to cited text no. 1      
2.Townley WA, Baker R, Sheppard N, Grobbelaar AO. Dupuytren's contracture unfolded. BMJ 2006;332:397-400.  Back to cited text no. 2  [PUBMED]  [FULLTEXT]  
3.Saar JD, Grothaus PC. Dupuytren's disease: an overview. Plast Reconstr Surg 2000;106:125-34.  Back to cited text no. 3  [PUBMED]  [FULLTEXT]  
4.Burge P. Genetics of Dupuytren's disease. Hand Clin 1999;15:63-71.   Back to cited text no. 4  [PUBMED]    
5.Gonzalez MH, Sobeski J, Grindel S, Chunprapaph B, Weinzweig N. Dupuytren's disease in African-Americans. J Hand Surg Br 1998;23:306-7.   Back to cited text no. 5  [PUBMED]    
6.Seyhan H, Kopp J, Schultze-Mosgau S, Horch RE. Increased metabolic activity of fibroblasts derived from cords compared with nodule fibroblasts sampling from patients with Dupuytren's contracture. Plast Reconstr Surg 2006;117:1248-52.  Back to cited text no. 6  [PUBMED]  [FULLTEXT]  
7.Tomasek JJ, Vaughan MB, Haaksma CJ. Cellular structure and biology of Dupuytren's disease. Hand Clin 1999;15:21-34.  Back to cited text no. 7  [PUBMED]    
8.James WD, Odom RB. The role of the myofibroblast in Dupuytren's contracture. Arch Dermatol 1980;116:807-11.  Back to cited text no. 8  [PUBMED]  [FULLTEXT]  
9.Hurst LC, Badalamente MA. Nonoperative treatment of Dupuytren's disease. Hand Clin 1999;15:97-107.  Back to cited text no. 9  [PUBMED]    
10.Ketchum LD, Donahue TK. The injection of nodules of Dupuytren's disease with triamcinolone acetonide. J Hand Surg 2000;25:1157-62.  Back to cited text no. 10      
11.Sanders JL, Dodd C, Ghahary A, Scott PG, Tredget EE. The effect of interferon-alpha2b on an in vitro model Dupuytren's contracture. J Hand Surg Am 1999;3:578-85.   Back to cited text no. 11      
12.Nedelec B, Shen YJ, Ghahary A, Scott PG, Tredget EE. The effect of interferon alpha 2b on the expression of cytoskeletal proteins in an in vitro model of wound contraction. J Lab Clin Med 1995;126:474-84.  Back to cited text no. 12  [PUBMED]    
13.McFarlane RM. Dupuytren's disease. In: McCarthy JG May JW, Littler JW, eds. Plastic Surgery. Vol 8, 1st ed. Philadelphia: WB Saunders; 1990. p. 5053-8.  Back to cited text no. 13      
14.McGrouther DA: Dupuytren's contracture. In Green DP, Hotchkiss RN, Pederson WC, eds: Operative Hand Surgery, vol 1, 4th ed. New York: Churchill Livingstone; 1998. p. 563-91.  Back to cited text no. 14      


    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4]



 

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