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Year : 2010  |  Volume : 76  |  Issue : 2  |  Page : 213-214

Leonine facies in an old man


Department of Skin and VD, MGIMS, Sevagram, Maharashtra, India

Date of Web Publication10-Mar-2010

Correspondence Address:
Atul Dongre
Department of Skin and VD, MGIMS, Sevagram, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0378-6323.60549

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How to cite this article:
Dongre A, Gondse S, Kar S. Leonine facies in an old man. Indian J Dermatol Venereol Leprol 2010;76:213-4

How to cite this URL:
Dongre A, Gondse S, Kar S. Leonine facies in an old man. Indian J Dermatol Venereol Leprol [serial online] 2010 [cited 2019 Aug 22];76:213-4. Available from: http://www.ijdvl.com/text.asp?2010/76/2/213/60549


A 68-year-old male farmer presented with multiple asymptomatic lesions over the face since childhood. These lesions gradually increased in size and number over a period of six decades to attend present size and shape. There was no history of bleeding from the lesions. On further probing, he mentioned similar kind of lesions involving face of his younger brother.

Examination revealed multiple, firm, skin colored, and few hyperpigmentd papules and nodules over the forehead, glabella, and nose alongwith obliteration of nasolabial fold [Figure 1].

A punch biopsy from one of the nodule over forehead was taken. Histopathological features of hematoxylin and eosin-stained section are shown in [Figure 2],[Figure 3],[Figure 4].


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1.Clarke J, Ioffreda M, Helm KF. Multiple familial trichoepitheliomas: A folliculosebaceous- apocrine genodermatosis. Am J Dermatopathol 2002;24:402-5.  Back to cited text no. 1  [PUBMED]    
2.Lee KH, Kim JE, Cho BK, Kim YC, Park CJ. Malignant transformation of multiple familial trichoepithelioma: Case report and literature review. Acta Dermatol Venereol 2008;88:43-6.  Back to cited text no. 2      
3.Salhi A, Bornholdt D, Oeffner F, Malik S, Heid E, Happle R, et al. Multiple familial trichoepithelioma caused by mutations in the cylindromatosis tumor suppressor gene. Cancer Res 2004;64:5113-7.  Back to cited text no. 3  [PUBMED]    
4.Harada H, Hashimoto K, Ko MS. The gene for multiple familial trichoepithelioma maps to chromosome 9p21. J Invest Dermatol 1996;107:41-3.  Back to cited text no. 4  [PUBMED]    
5.Young AL, Kellermayer R, Szigeti R, Teszas A, Azmi S, Celebi JT. CYLD mutations underlie Brooke-Spiegler, familial cylindromatosis and multiple familial trichoepithelioma syndromes. Clin Genet 2006;70:246-9.  Back to cited text no. 5      
6.Biggs PJ, Wooster R, Ford D, Chapman P, Mangion J, Quirk Y, et al. Familial cylindromatosis gene localised to chromosome 16q12-q13: Evidence for its role as a tumour suppressor gene. Nat Gene 1995;11:441-3.  Back to cited text no. 6      
7.Shaffelburg M, Miller R. Treatment of multiple trichoepithelioma with electrosurgery. Dermatol Surg 1998;24:1154-6.  Back to cited text no. 7  [PUBMED]    
8.Duhra P, Paul JC. Cryotherapy for multiple trichoepithelioma. J Dermatol Surg Oncol 1988;14:1413-5.  Back to cited text no. 8  [PUBMED]    
9.Flores JT, Apfelberg DB, Maser MR, Lash H. Trichoepithelioma: Successful treatment with the argon laser. Plast Reconstr Surg 1984;74:694-8.  Back to cited text no. 9  [PUBMED]    
10.Sawchuk WS, Heald PW. CO2 laser treatment of trichoepithelioma with focused and defocused beam. J Dermatol Surg Oncol 1984;10:905-7.  Back to cited text no. 10  [PUBMED]    


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