|Year : 2009 | Volume
| Issue : 6 | Page : 631-633
Nail pitting and onycholysis
Vikrant M Jadhav, Pradeep M Mahajan, Chandrakant B Mhaske
Department of Skin & VD, B. J. Medical College, Pune, India
|Date of Web Publication||12-Nov-2009|
Vikrant M Jadhav
Ward -33, Department of Skin & VD, Sasson Hospital, Pune - 1, Maharastra
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Jadhav VM, Mahajan PM, Mhaske CB. Nail pitting and onycholysis. Indian J Dermatol Venereol Leprol 2009;75:631-3
| Introduction|| |
Nail disorders comprise of approximately 10% of all dermatologic conditions.  The nail unit may show specific changes that are markers for a wide range of systemic disorders. Furthermore, there are a number of heritable and non-heritable syndromes in which the nail disease is an integral part of the multisystem disorder.
Sometimes a developmental defect may be limited to the nail. Additionally, a number of dermatologic disorders may affect the nail. Consequently no dermatologic examination is complete without a detailed examination of the nails. However, the nail still remains an understudied, underutilized, yet quite an accessible structure that lends itself for examination and evaluation. Pathology in any portion of the nail apparatus results in an abnormal nail sign. Nail signs occur in the nail plate and the paronychial tissues, including the nail bed, nail fold, and the visible portion of the lunula. Among the various nail signs, we will concentrate on two common nail signs in this article (1) nail pitting (2) onycholysis.
| Nail Pitting|| |
Pits are superficial depressions within the nail plate that vary in morphology and distribution.
A pit indicates a defect in the uppermost layer of the nail plate, which arises from the proximal nail matrix. 
| Pathogenesis|| |
Clusters of parakeratotic cells in the stratum corneum disrupt the process of normal keratinization. As the nail plate grows outward, these parakeratotic foci are exposed to the surrounding environment and there is a gradual sloughing of these cells leaving a distinct depression within the nail plate. 
Although nail pitting is primarily associated with disease of the proximal nail matrix, the proximal nail fold can also contribute to this process, because the ventral surface of the proximal nail fold closely overlies the nail matrix. It is believed that the parakeratotic and inflammatory cells originating from this structure become entrenched into the surface of the nail plate as parakeratotic foci. 
| Causes of Pitting|| |
| Types of Pitting|| |
- Irregular pitting: - seen in psoriasis. Usually shallow and small (< 1 mm).
- Geometric pitting: - multiple small superficial pits, which are regularly distributed in a geometric pattern along longitudinal or transverse lines. Seen in alopecia areata. 
- Coarse pitting and cross ridging: - very irregular pits seen in eczematous dermatitis. 
- Elkonyxis: - very large pits, seen in syphilis, Reiters disease, after trauma, and after etretinate and isotretinoin therapy. ,
- Rosenaus depression: - small pitted craters found on the middle and ring finger and are reported to occur in diabetes mellitus. 
| Important Facts About Nail Pitting|| |
- Pits more commonly affect finger nails than toe nails.
- Isolated nail involvement with more than 20 pits are suggestive of having a psoriatic etiology. 
- A rare uniform pitting of the whole nail plate appears to be a developmental anomaly in its own right. 
- Pitted nail grows faster as compared to a normal nail.
- The distance of a pit from the proximal nail fold is suggestive of the length of time for which the matrix was affected by the pathology. 
- A deeper depression would be indicative of intermediate and ventral matrix involvement, in addition to the dorsal section. 
- The amount of time for which the matrix is free of any pathology directly corresponds to the length of normal nail plate growth observed. 
- Pitting is occasionally helpful in building a clinical case for psoriatic arthritis, in the absence of other definitive markers, especially where it is the only cutaneous manifestation of psoriasis.
| Onycholysis|| |
Onycholysis is defined as a distal or distal lateral separation of the nail plate from the underlying and/or lateral supporting structures (nail bed, hyponychium, lateral nail fold). When the separation begins proximally near the nail matrix, the process is called onychomadesis. Onycholysis is a common disorder. 
The pathogenesis in a number of cases may be unclear. It is known that a normal nail bed does not have a granular layer. Any process that disturbs the normal formation of the nail bed, like psoriasis or lichen planus, which can form a nail bed granular layer, can cause onycholysis. Trauma, be it physical, irritation-induced, or allergic can cause onycholysis.
The area of separation below the nail plate appears white or yellow due to air beneath the nail. Discoloration may occur from the accumulation of bacteria, most commonly pseudomonas or yeast, for example, Candida albicans. Color change such as green may be seen due to pyocyanin from pseudomonas, black or blue discoloration may also be seen.
Onycholysis can be classified as primary (idiopathic) and secondary.
| Idiopathic|| |
This is a painless separation of the nail from the nail bed, which occurs without apparent cause. Overzealous manicure, frequent wetting, and cosmetic solvents may be the cause. Minor trauma can cause this condition in persons who keep their nails abnormally long. The affected nail grows very quickly. 
Pain occurs only if there is further separation as a result of trauma or if active infection supervenes. The infective organisms include Candida albicans and pseudomonas pyocyanea.
The condition is most commonly seen in women and many cases return to normal after a few months. The longer it lasts, the less likely is the nail to become reattached, due to keratinization of the exposed nail bed.
| Secondary|| |
It can be further classified into:
- Dermatologic causes
- Systemic causes
The numerous dermatologic conditions leading to onycholysis include psoriasis, fungal infection, Reiters syndrome, hyperhydrosis, pemphigus vulgaris, pellagra, leprosy, syphilis, occupational trauma, psoriatic arthritis, and so on.
Numerous drugs have been reported to induce onycholysis.
Cefaloridin, chloramphenicol, chlortetracycline, doxycycline, minocycline. Chemotherapeutic agents;- Adriamycin, bleomycin, 5-fluorouracil, mitoxantrone, paclitaxel, and docetaxel.
Acridine, captopril, phenothiazines, retinoids, sulfa drugs, and thiazides.
In drug-induced photo-onycholysis, the lateral margins of the nails are never involved and thumbs are also rarely affected. The nail is tender and painful in tetracycline or psoralen-induced photo-onycholysis. Photosensitivity, nail discoloration, and onycholysis are typical of the former (Segal's triad). 
Thyroid diseases, Yellow nail syndrome, Shell nail syndrome, Bronchogenic carcinoma, Multiple myeloma, Scleroderma, Anemia, Peripheral vascular diseases, and diabetes mellitus.
In this type of onycholysis the free edge of the nail is undulated and curved upward, characteristically seen in thyrotoxicosis. 
Nail cosmetics, Pregnancy, Hereditary.
| References|| |
|1.||Guidelines/Outcomes Committee, American Academy of Dermatology. Guidelines of care for nail disorders. J Am Acad Dermatol 1996;34:375-8. |
|2.||Zaias N. The nail in health and disease, 2 nd ed Norwalk: Appleton and lange; 1990. |
|3.||Tosti A, Piraccani B, Dermatologic diseases. In: Scher RK, editor. Nails Diagnosis, Therapy and Surgery, 3 rd edition. Phiadelphia: Saunders; 2005. p. 116. |
|4.||Baran R, Dawber RPR. Physical signs. In: Baran R, Dawber RPR, editors. Diseases of the nail and their management. 2 nd ed. Oxford: Blackwell Scientific Publications; 1994. p. 35-80. |
|5.||Yung A, Johnson P, Goodfield MJD. Isotretinoin - induced elkonyxis. Br J Dermatol 2005;153:669-70. |
|6.||Greene RA, Scher RK. Nail Changes associated with diabetes mellitus. J Am Acad Dermatol 1987;16:1015-21. |
|7.||Baran R, Dawber RPR. The nail in dermatologic diseases. In: Baran R, Dawber RPR editor. Diseases of nail and their management, 2 nd edition. Oxford: Blackwell Scientific Publications; 1994. p. 135-73. |
|8.||Daniel CR 3rd. Onycholysis: an overview. Seminars in Dermatology 1991;10:34-40. |
|9.||Dawber RP, Samman PD, Bottoms E. Fingernail growth in idiopathic and psoriatic onycholysis. Br J Dermatol 1971;85:558-60. |
|10.||Baran R, Juhlin L. Photo-onycholysis due to tetracycline. Photodermatol Photoimmunol Photomed 2002;18:202-7. |
|11.||Tosti A, Baran R, Dawber RPR. The nail in systemic diseases and drug induced changes. In: Baron R, Dawber RPR, editors. Diseases of the nail and their management. 2 nd edition. Oxford: Blackwell Scientific Publications; 1994. p. 175-261. |
|This article has been cited by|
||Nail Deformities and Injuries
| ||James Rory J. Tucker |
| ||Primary Care: Clinics in Office Practice. 2015; 42(4): 677 |
|[Pubmed] | [DOI]|
||Diagnosis and Management of Nail Disorders in Children
| ||Derek H. Chu,Adam I. Rubin |
| ||Pediatric Clinics of North America. 2014; |
|[Pubmed] | [DOI]|
||Nail abnormalities associated with systemic pathologies
| ||Martin N. Zaiac,Ashley Walker |
| ||Clinics in Dermatology. 2013; 31(5): 627 |
|[Pubmed] | [DOI]|
||Elkonyxis in association with washboard nail and 20-nail dystrophy
| ||Young Bok Lee,Min Seok Cheon,Young Sun Eun,Hyun Jeong Park,Baik Kee Cho |
| ||International Journal of Dermatology. 2013; : n/a |
|[Pubmed] | [DOI]|
||Nails in systemic disease
| ||Singh, G. |
| ||Indian Journal of Dermatology, Venereology and Leprology. 2011; 77(6): 646-651 |
||Facial psoriasis. A case report with good response to topical tacrolimus treatment | [Psoriasis facial. Comunicación de un caso con buena respuesta al tratamiento con tacrolimus tópico]
| ||Martínez, R.P., García, C.A.M., González, M.G. |
| ||Dermatologia Revista Mexicana. 2011; 55(3): 159-164 |