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 ORIGINAL ARTICLE
Year : 2009  |  Volume : 75  |  Issue : 6  |  Page : 579--582

Association of HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome among Indians


1 Dr. Rasiklal Shah Sarvajanik Hospital, Modasa 383315, India
2 Shri B. M. Shah College of Pharmaceutical Education and Research, Modasa 383315, India
3 Department of Molecular Biology, Krishna Institute of Medical Sciences, Hyderabad 500003, India
4 Deparment of Animal Biotechnology, Anand Agricultural University, Anand 388001, India
5 Institute of Human Genetics, Ahmedabad 380015, India
6 Deep Hospital, Modasa 383315, India
7 Department of Pharmacology, L M College of Pharmacy, Ahmedabad 380009, India

Correspondence Address:
Timir Y Mehta
Dr. Rasiklal Shah Sarvajanik Hospital, Modasa - 383 315, Gujarat
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0378-6323.57718

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Background: Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis are severe cutaneous reactions caused by certain drugs, including antiepileptic carbamazepine. A strong association has been reported between human leucocyte antigen (HLA)-B*1502 and carbamazepine-induced SJS in Han Chinese patients. European studies suggested that HLA-B*1502 is not a universal marker but is ethnicity-specific for Asians. Aim: To study the association between HLA-B*1502 and carbamazepine-induced SJS in Indian patients. Methods: Eight individuals who fulfilled the diagnostic criteria of SJS induced by carbamazepine were identified and HLA-B molecular typing was performed. HLA-B genotyping was carried out by polymerase chain reaction using sequence-specific primers. Results: Out of eight patients studied for genotype, six patients were found to have the HLA-B*1502 allele. Conclusion: This study suggests an association between HLA-B*1502 and carbamazepine-induced SJS in Indian patients.






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