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Year : 2009  |  Volume : 75  |  Issue : 4  |  Page : 363--367

Comparison of seropositivity of human T lymphotropic virus type 1 in mycosis fungoides patients and normal volunteers: A case-control study and review of literature

1 Razi Skin Hospital, Department of Dermatology, Medical Sciences/University of Tehran, Tehran, Iran
2 Center for Research & Training in Skin Diseases & Leprosy, Medical Sciences/University of Tehran, Tehran, Iran
3 Razi Skin Hospital, Department of Dermatology and Center for Research & Training in Skin Diseases & Leprosy, Medical Sciences/University of Tehran, Tehran, Iran

Correspondence Address:
Farzam Gorouhi
Unit 10, #19, Boostan Building, Sharifimanesh Ave., Elahieh St., Tehran
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0378-6323.53131

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Background: There have been controversial reports about the possible association between mycosis fungoides (MF), its leukemic variant Sιzary syndrome (SS) and human T lymphotropic virus type 1 (HTLV-1) in different geographical regions. Aims: The purpose of this study was to explore any association between MF and presence of HTLV-1 infection in Iran. Methods: In a case-control setting, 150 clinically and histopathologically proven MF patients had been admitted to the tertiary referral skin center during a 10-year period and another 150 normal volunteers had been compared with each other for the presence of HTLV-1 infection. Enzyme-linked immunosorbent assay (ELISA) was used to detect antibodies against HTLV-1, and positive results were confirmed with western blotting. Results: Only three MF patients had HTLV-1 infection, whereas two cases of normal subjects had the infection ( P > 0.05). The only three seropositive MF patients were male and from North-Eastern Iran . Conclusion: This study showed that MF does not correlate with HTLV-1 infection in Iran.


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