Indexed with PubMed and Science Citation Index (E) 
Users online: 1317 
     Home | Feedback | Login 
About Current Issue Archive Ahead of print Search Instructions Online Submission Subscribe What's New Contact  
  Navigate here 
   Next article
   Previous article 
   Table of Contents
 Resource links
   Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
   Article in PDF (121 KB)
   Citation Manager
   Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
* Registration required (free)  

  In this article
   What is your Dia...
   Article Figures

 Article Access Statistics
    PDF Downloaded278    
    Comments [Add]    
    Cited by others 4    

Recommend this journal


Year : 2009  |  Volume : 75  |  Issue : 3  |  Page : 330

Vesicular rash in a newborn

1 Department of Dermatology, Venereology, Hospital S. Joćo, EPE, Portugal
2 Department of Dermatology, Venereology, Hospital S. Joćo, EPE; Faculty of Medicine, Oporto University, Portugal
3 Department of Pathology, Hospital S. Joćo, EPE, Portugal

Correspondence Address:
A Nogueira
Department of Dermatology and Venereology, Hospital S. Joćo, EPE, Alameda Prof. Hernāni Monteiro, 4200 - 319 Porto
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0378-6323.51255

Rights and Permissions

How to cite this article:
Nogueira A, Lisboa C, Eloy C, Mota A, Azevedo F. Vesicular rash in a newborn. Indian J Dermatol Venereol Leprol 2009;75:330

How to cite this URL:
Nogueira A, Lisboa C, Eloy C, Mota A, Azevedo F. Vesicular rash in a newborn. Indian J Dermatol Venereol Leprol [serial online] 2009 [cited 2020 May 26];75:330. Available from: http://www.ijdvl.com/text.asp?2009/75/3/330/51255

A full-term female newborn, with no history of consanguinity in the parents, presented at birth with generalized vesicles, pustules and blisters, appearing in crops, with preferential distribution on the limbs. She was otherwise well and was afebrile. A herpetic infection was considered, so after taking swabs, she was started on intravenous acyclovir. After an initial good response, the dermatosis worsened, assuming a roughly linear pattern [Figure 1] and manifested with an impressive blood eosinophilia. The infectious cause was excluded (Tzanck test showed no giant cells, and there was a negative PCR for HSV, VZV and bacteriologic examination), and a skin biopsy was performed, which revealed spongiotic intraepidermal vesicles with a rich eosinophil infiltrate [Figure 2]. Her mother recalled a history of a similar rash in her infancy, and displayed faint linear hypopigmented streaks on her calves, which were better observed with the Wood's lamp [Figure 3], conical incisor teeth and vertex alopecia.

  What is your Diagnosis ? Top

Click here to view answer. View Answer

  References Top

1.Ehrenreich M, Tarlow MM, Godlwska-Janusz E, Schwartz RA. Incontinentia pigmenti (Bloch Sulzberger Syndrome): A systemic disorder. Cutis 2007;79:355-62.  Back to cited text no. 1    
2.Berlin AL, Paller AS, Chan LW. Incontinentia pigmenti: A review and update on the molecular basis of pathophysiology. J Am Acad Dermatol 2002;47:169-87.  Back to cited text no. 2    
3.Nelson DL. NEMO, NFkB signaling and incontinentia pigmenti. Cur Op Gen Develop 2006;16:282-8.  Back to cited text no. 3    
4.Stitt W, Scott G, Caserta M, Goldsmith L. Coexistence of incontinentia pigmenti and neonatal herpes simplex infection. Pediatr Dermatol 1998;15:112-5.  Back to cited text no. 4    
5.Aradhya S, Woffendin H, Jakins T, Bardaro T, Esposito T, Smahi A, et al . A recurrent deletion in the ubiquitously expressed NEMO (IKK-g) gene accounts for the vast majority of incontinentia pigmenti mutations. Hum Mol Genet 2001;10:2171-9.  Back to cited text no. 5  [PUBMED]  [FULLTEXT]


  [Figure 1], [Figure 2], [Figure 3]

This article has been cited by
1 Cephalometric skeletal evaluation of patients with Incontinentia Pigmenti
Marcia Angelica Peter Maahs,Ana Elisa Kiszewski,Rafael Fabiano Machado Rosa,Fernanda Diffini Santa Maria,Frederico Ballvé Prates,Paulo Ricardo Gazzola Zen
Journal of Oral Biology and Craniofacial Research. 2014; 4(2): 88
[Pubmed] | [DOI]
2 Incontinentia pigmenti (Bloch–Siemens syndrome)
Yaqin Zhang,Venkatesh Pyla,Xianling Cong
European Journal of Pediatrics. 2013; 172(8): 1137
[Pubmed] | [DOI]
3 Neurological involvement in incontinentia pigmenti
Mustafa Aydin,Nilay Hakan,Nihal Demirel,Ugur Deveci,Aysegul Zenciroglu,Nurullah Okumus
European Journal of Pediatrics. 2013;
[Pubmed] | [DOI]
4 Do you know this syndrome? | [Vocź conhece esta sķndrome?]
Succi, I.B., Rosman, F.C., de Oliveira, E.F.
Anais Brasileiros de Dermatologia. 2011; 86(3): 608-610


Print this article  Email this article
Previous article Next article


Online since 15th March '04
Published by Wolters Kluwer - Medknow