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Year : 2009  |  Volume : 75  |  Issue : 3  |  Page : 236--244

Human papillomavirus and genital cancer

Division of Infectious Diseases, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, USA

Correspondence Address:
Alwyn Rapose
Division of Infectious Diseases, University of Texas Medical Branch, Rte. 0435, 301 University Blvd., Galveston, TX 77555-0435
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0378-6323.48429

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Human papillomavirus (HPV) is one of the most common sexually transmitted infections world-wide. Low-risk HPV-types are associated with genital warts. Persistent infection with high-risk HPV-types is associated with genital cancers. Smoking and HIV infection have consistently been associated with longer duration of HPV infection and risk for genital cancer. There is an increasing incidence of anal cancers, and a close association with HPV infection has been demonstrated. Receptive anal sex and HIV-positive status are associated with a high risk for anal cancer. Two HPV vaccines are now available and offer protection from infection by the HPV-types included in the vaccine. This benefit is maximally seen in young women who were uninfected prior to vaccination.


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Online since 15th March '04
Published by Wolters Kluwer - Medknow