IADVL
Indexed with PubMed and Science Citation Index (E) 
 
Users online: 2126 
     Home | Feedback | Login 
About Current Issue Archive Ahead of print Search Instructions Online Submission Subscribe What's New Contact  
  NAVIGATE Here 
    Next article
    Previous article
    Table of Contents

 RESOURCE Links
    Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
  Related articles
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed4414    
    Printed90    
    Emailed2    
    PDF Downloaded278    
    Comments [Add]    
    Cited by others 2    

Recommend this journal

 

 BRIEF REPORT
Year : 2008  |  Volume : 74  |  Issue : 6  |  Page : 628--631

Topical immunotherapy with diphenylcyclopropenone in vitiligo: A preliminary experience


1 Department of Dermatology, Jahrom University of Medical Sciences, Jahrom, Iran
2 Department of Dermatology, Jahrom University of Medical Sciences, Jahrom; Education Development Center, School of Medicine, Shiras University of Medical Sciences, Shiraz, Iran

Correspondence Address:
Shahin Aghaei
Department of Dermatology, Jahrom University of Medical Sciences, School of Medicine, Jahrom
Iran
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0378-6323.45108

Rights and Permissions

Background: Despite recent significant therapeutic advances, vitiligo remains a clinical conundrum. Topical immunotherapy has been extensively tested in the treatment of various dermatologic disorders, especially those believed to have an immunologic basis. Aim: To evaluate the role of topical diphenylcyclopropenone (DPCP) in the treatment of vitiligo. Methods: Nineteen patients with limited vitiligo lesions were enrolled in this study. After sensitization with 2% lotion of DPCP in acetone, progressively higher concentrations beginning at 0.001% up to 2% were applied weekly for 6 months to the depigmented skin lesions. Results: Thirteen of the 19 patients were evaluated at the end of 6 months. Four patients with focal vitiligo, one patient with vitiligo vulgaris, and three patients with segmental vitiligo showed marked (grade 3) repigmentation. Conclusion: Marginal and central repigmentation with hyperpigmented borders was seen in the majority of lesions. Further controlled trials should be undertaken to evaluate the use of topical DPCP in vitiligo.






[FULL TEXT] [PDF]*


        
Print this article     Email this article

Online since 15th March '04
Published by Wolters Kluwer - Medknow