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 NET STUDY
Year : 2008  |  Volume : 74  |  Issue : 5  |  Page : 550-

Is CCR7 a potential target for biologic therapy in psoriasis?: Increased expression of CCR7 in psoriasis vulgaris


1 Department of Dermatology, Xi-Jing Hospital, The Fourth Military Medical University, Shannxi; Department of Dermatology, General Hospital of Beijing Military of PLA, Beijing, P. R, China
2 Department of Dermatology, Xi-Jing Hospital, The Fourth Military Medical University, Shannxi, P. R, China

Correspondence Address:
YuFeng Liu
Department of Dermatology, the affiliated Xi-Jing Hospital, the Fourth Military Medical University, Shannxi
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0378-6323.44338

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Background: Activated T cells present in psoriatic plaques play a key role in the pathogenesis of psoriasis. CCR7 on T cells plays a crucial role in native immune response and formation of secondary lymphoid organ. Aims: To determine whether differential expression and functions of the CCR7 occur in psoriasis patients in China, we examined CCR7 on T cells from normal and psoriasis subjects. Methods: Skin specimens and T cells from 33 patients and 22 healthy controls were analyzed by immunohistology, flow cytometry, and RT-PCR. Results: Patients with psoriasis had a skewed distribution of T lymphocytes, with an increased level of CCR7 + T lymphocytes compared to healthy controls (P < 0.01) By flow cytometry, it was found that CCR7 was selectively, frequently, and functionally expressed on CD4 + (20.56.8%)but not on CD8 + (9.53.4%) T cells from patients with psoriasis, whereas this phenomenon was not seen in normal subjects. Through RT-PCR it was also found that CCR7 was highly expressed on T cells in patients with psoriasis than in healthy controls in the level of gene. Conclusions: Patients with psoriasis had a skewed distribution of T lymphocytes, with an increased level of CCR7 + T lymphocytes compared to healthy controls. CD4 + CCR7 + T cells had abnormal expression, which might induce protraction and persistence of psoriasis.






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