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 NET STUDY
Year : 2008  |  Volume : 74  |  Issue : 1  |  Page : 80-

A study of oxidative stress in paucibacillary and multibacillary leprosy


1 CHC, Iriveri, Kannur, India
2 Department of Dermatology and Venereology, Medical College, Calicut, Kerala, India

Correspondence Address:
P Jyothi
'Jyothis', Trichambaram, Taliparamba, Kannur - 670 141, Kerala
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0378-6323.38428

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Background: The study and assessment of oxidative stress plays a significant role in the arena of leprosy treatment. Once the presence of oxidative stress is proved, antioxidant supplements can be provided to reduce tissue injury and deformity. Aim: To study oxidative stress in paucibacillary (PB) and multibacillary (MB) leprosy and to compare it with that in a control group. Methods: Fifty-eight untreated leprosy patients (23 PB and 35 MB cases) were studied and compared with 58 healthy controls. Superoxide dismutase (SOD) level as a measure of antioxidant status; malondialdehyde (MDA) level, an indicator of lipid peroxidation; and MDA/SOD ratio, an index of oxidative stress were estimated in the serum. Results: The SOD level was decreased in leprosy patients, especially in MB leprosy. The MDA level was increased in PB and MB leprosy. The MDA/SOD ratio was significantly elevated in MB patients. There was a steady increase in this ratio along the spectrum from tuberculoid to lepromatous leprosy (LL). Conclusion: There is increased oxidative stress in MB leprosy, especially in LL. This warrants antioxidant supplements to prevent tissue injury.






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Online since 15th March '04
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