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 BRIEF REPORT
Year : 2008  |  Volume : 74  |  Issue : 1  |  Page : 32--34

Ligand-binding prediction for ErbB2, a key molecule in the pathogenesis of leprosy


Department of Clinical Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand

Correspondence Address:
Viroj Wiwanitkit
Department of Clinical Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok- 10330
Thailand
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0378-6323.38404

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Background and Aims: Mycobacterium leprae is an obligate intracellular pathogen. Ligand-binding is an important factor in the success of chemoprevention and chemotherapy. A new drug that can inhibit M. leprae binding to and activation of, ErbB2 and Erk1/2 in primary Schwann cells is the new therapeutic option. However, the ligand-binding pattern of ErbB2 has never been clarified. Methods: In this work, the author performed a ligand-binding prediction for ErbB2 using a new bioinformatics tool. Results: According to this study, nine strong possible ligands can be identified. Conclusion: These sites can be useful for further drug-development studies.






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Online since 15th March '04
Published by Wolters Kluwer - Medknow