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Year : 2007  |  Volume : 73  |  Issue : 4  |  Page : 271-272

Comedone-like changes overlying neurofibromas

Department of Dermatology and STD, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry - 605 006, India

Correspondence Address:
Devinder Mohan Thappa
Department of Dermatology and STD, JIPMER, Pondicherry - 605 006
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0378-6323.33648

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How to cite this article:
Laxmisha C, Thappa DM. Comedone-like changes overlying neurofibromas. Indian J Dermatol Venereol Leprol 2007;73:271-2

How to cite this URL:
Laxmisha C, Thappa DM. Comedone-like changes overlying neurofibromas. Indian J Dermatol Venereol Leprol [serial online] 2007 [cited 2020 May 28];73:271-2. Available from: http://www.ijdvl.com/text.asp?2007/73/4/271/33648


Three females aged 35, 38 and 16 years with type 1 neurofibromatosis, were seen in the skin department. None of them had a similarly affected first degree relative. All of them had more than six cafe-au-lait macules with multiple cutaneous neurofibromas. Two of them had more than two iris Lisch nodules. On close examination, some of the cutaneous neurofibromas showed follicular dilatation and plugging resembling comedones on their surface [Figure - 1]. Histological examination of these nodules were diagnostic of neurofibroma with dilated follicular ostia filled with keratinous plugs and pilar differentiation.

Pilar dysplasia and folliculosebaceous differentiation have been described in neurofibromatosis by del Rio et al. in two patients. [1] They considered it to be a stimulation phenomenon reflecting the essential role of the stroma in many cutaneous epithelial hyperplasias, hamartomas and possibly in some neoplasms. Various growth factors and their receptors are present in cutaneous neurofibromas. Mast cells, nonspecific cholinesterase, S-100 protein, myelin basic protein and factor XIIIa have been demonstrated in neurofibromas. [2] Epidermal follicular differentiation may follow induction by several dermal mesenchymal proliferations including dermatofibroma, focal mucinosis, scar, nevus sebaceous, dermatofibrosarcoma protuberans and hemangioma. [3] Follicular induction may yield a spectrum of follicular differentiation from germinative basaloid hyperplasia to advanced follicle formation. The production of the comedones in the overlying skin of neurofibromas could be due to the defective formation of follicle ostia.

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1.del Rio E, Sanchez Yus E, Simon P, Vazquez Veiga HA. Stimulation of folliculo sebaceous proliferations by neurofibromas: A report of two cases. J Cutan Pathol 1998;25:228-32.  Back to cited text no. 1      
2.Somach S, Morgan M. Benign keratosis with a spectrum of follicular differentiation: A case series and investigation of a potential role of human papilloma virus. J Cutan Pathol 2001;28:156-9.  Back to cited text no. 2  [PUBMED]  [FULLTEXT]  
3.Weedon D. Neural and neuroendocrine tumors. In : Skin pathology. 2 nd ed. Churchill Livingstone Publication: London; 2002. p. 977-99.  Back to cited text no. 3      


  [Figure - 1]


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