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LETTER TO EDITOR
Year : 2007  |  Volume : 73  |  Issue : 4  |  Page : 265

Type I hypersensitivity to Parthenium hysterophorus in patients with parthenium dermatitis


Department of Dermatology & Venereology, All India Institute of Medical Sciences, New Delhi - 110 029, India

Correspondence Address:
Kaushal K Verma
Department of Dermatology & Venereology, All India Institute of Medical Sciences, New Delhi-110029
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0378-6323.33641

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How to cite this article:
Verma KK. Type I hypersensitivity to Parthenium hysterophorus in patients with parthenium dermatitis. Indian J Dermatol Venereol Leprol 2007;73:265

How to cite this URL:
Verma KK. Type I hypersensitivity to Parthenium hysterophorus in patients with parthenium dermatitis. Indian J Dermatol Venereol Leprol [serial online] 2007 [cited 2019 Aug 23];73:265. Available from: http://www.ijdvl.com/text.asp?2007/73/4/265/33641


Sir,

I read with interest the article by Lakshmi et al. [1] In this article the authors have suggested that both type I hypersensitivity and type IV hypersensitivity are responsible for dermatitis in parthenium dermatitis patients, and they have tried to demonstrate this by doing prick test and serum IgE levels in these patients. The majority of their patients were atopics. It is well known that atopic individuals are more susceptible to develop allergic response to various antigenic stimuli and have elevated IgE levels. [2] Immunologic abnormalities of type I and type IV reactions have been described in patients with atopic dermatitis. [3] Immunologic triggers are aeroallergens, food allergens, microbial products, autoallergens and contact allergens. They enhance IgE production by B lymphocytes with an increased secretion of interleukin 4, interleukin 5 and interleukin 13. [2]

Atopics are a more susceptible to develop contact allergy to compositae plants also. [4],[5] In this study, it seems atopic individuals have developed parthenium dermatitis and this atopic state may have resulted in positive prick test and elevated IgE levels in these patients, which may not have been actually due to parthenium. The situation may have been different in non-atopic parthenium dermatitis patients. Therefore, positive prick test and elevated IgE levels in their patients do not conclusively prove that these were due to parthenium only and not because of some other stimuli. Hence a credible evidence of type I hypersensitivity due to Parthenium hysterophorus is lacking in this study. I dare to suggest that the authors should have demonstrated 'Parthenium hysterophorus' -specific IgE by using methods like ELISA to confirm the presence of these IgE antibodies due to Parthenium hysterophorus antigen to suggest the role of type I hypersensitivity in this disease.

 
  References Top

1.Lakshmi C, Srinivas CR. Type I hypersensitivity to parthenium hysterophorus in patients with parthenium dermatitis. Indian J Dermatol Venereol Leprol 2007;73:103-5.  Back to cited text no. 1  [PUBMED]  Medknow Journal  
2.Pastar Z, Lipozencic J, Ljubojevic S. Etiopathogenesis of atopic dermatitis: An overview. Acta Dermatovenerol Croat 2005;13:54-62.  Back to cited text no. 2      
3.Wollenberg A, Kraft S, Oppel T, Bieber T. Atopic dermatitis: pathogenetic mechanisms. Clin Exp Dermatol 2000;25:530-4.  Back to cited text no. 3  [PUBMED]  [FULLTEXT]  
4.Jovanovic M, Poljacki M, Duran V, Vujanovic L, Sente R, Stojanovic S. Contact allergy to Compositae plants in patients with atopic dermatitis. Med Pregl 2004;57:209-18.  Back to cited text no. 4      
5.Nettis E, Giordano D, Soccio A, Ferrannini A, Tursi A. Frequency of contact allergy to composite extracts in patients with atopic dermatitis. Contact Dermatitis 2002;47:169-70.  Back to cited text no. 5  [PUBMED]  [FULLTEXT]  



This article has been cited by
1 Type I hypersensitivity to Parthenium hysterophorus in patients with parthenium dermatitis
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Indian journal of dermatology, venereology and leprology. 2007; 73 (4): 265-265
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2 Parthenium dermatitis caused by immediate and delayed hypersensitivity
Lakshmi C
Indian journal of dermatology, venereology and leprology. 2007; 57(1): 64-65
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3 Parthenium: A wide angle view
Lakshmi, C., Srinivas, C.
Indian Journal of Dermatology, Venereology and Leprology. 2007; 73(5): 296-306
[Pubmed]



 

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