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Year : 2007  |  Volume : 73  |  Issue : 4  |  Page : 240--242

Detection of pemphigus autoantibodies in healthy relatives of Turkish patients with pemphigus

1 Department of Dermatology, Göztepe Training and Research Hospital, Istanbul, Turkey
2 Department of Pathology, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey

Correspondence Address:
Ozgur Emek Kocaturk
Bozova Sk. Bayirbasi Apt. No: 4/10 Mecidiyekoy, Sisli, Istanbul
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0378-6323.32889

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Background: Pemphigus autoantibodies have been reported in healthy relatives of pemphigus patients suggesting a genetic predisposition in the pathogenesis of the disease. Aims: To test for the presence of pemphigus autoantibodies in healthy relatives of Turkish patients of pemphigus. Methods: The study group comprised 45 pemphigus patients, 75 unaffected family members and 47 healthy individuals in the control group. Direct and indirect immunofluorescence techniques were performed to determine the presence of pemphigus autoantibodies. Results: By indirect immunofluorescence staining, circulating pemphigus autoantibodies were found in 26.7% of the relatives and in only two of the controls ( P value = 0.0001). A direct immunofluorescence technique revealed positive results in three (4%) of the relatives and none of the controls. Conclusion: The presence of pemphigus autoantibodies in clinically healthy relatives indicates that genetic predisposition is necessary but not sufficient for the development of clinical disease.


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Online since 15th March '04
Published by Wolters Kluwer - Medknow