IADVL
Indexed with PubMed and Science Citation Index (E) 
 
Users online: 3792 
     Home | Feedback | Login 
About Current Issue Archive Ahead of print Search Instructions Online Submission Subscribe What's New Contact  
  Navigate here 
  Search
 
   Next article
   Previous article 
   Table of Contents
  
 Resource links
   Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
  Related articles
   Article in PDF (141 KB)
   Citation Manager
   Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
* Registration required (free)  

 
  In this article
   Abstract
   Conclusion
   References
   Article Figures
   Article Tables

 Article Access Statistics
    Viewed20943    
    Printed434    
    Emailed19    
    PDF Downloaded1923    
    Comments [Add]    
    Cited by others 24    

Recommend this journal

 


 
FOCUS
Year : 2007  |  Volume : 73  |  Issue : 1  |  Page : 60-62

Mesotherapy


Consultant Dermatologist, Malar Hospital, Chennai, India

Correspondence Address:
Maya Vedamurthy
AB-76, 1st Street, Anna Nagar, Chennai-600010
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0378-6323.30661

Rights and Permissions

  Abstract 

Mesotherapy is a technique which involves microinjections of conventional homeopathic medication and/ or vitamins into the mesoderm or middle layer of the skin to promote healing or corrective treatment to a specific area of the body. It is a debatable addition in the therapeutic armamentarium in the management of skin rejuvenation. However, dermatologists have to use this cautiously and judiciously as at present there is a lot of controversy regarding its efficacy and safety despite the fact that mesotherapy is gaining popularity in the West.


Keywords: Current status, Mesotherapy


How to cite this article:
Vedamurthy M. Mesotherapy. Indian J Dermatol Venereol Leprol 2007;73:60-2

How to cite this URL:
Vedamurthy M. Mesotherapy. Indian J Dermatol Venereol Leprol [serial online] 2007 [cited 2019 Apr 23];73:60-2. Available from: http://www.ijdvl.com/text.asp?2007/73/1/60/30661


Mesotherapy was invented by the Frenchman Dr. Michel Pistor in 1958 to treat conditions in rheumatology, sports, traumatology, infectious diseases, vascular diseases and mainly as a pain-relieving technique. The North American experience began when Dr. Lionel Bissoon learned the technique in France and later popularized it in America. Its cosmetic applications, particularly for removal of fat and cellulite have recently received attention in the United States.

Applications of mesotherapy in dermatology

Mesotherapy is used in the treatment of:

  1. Cellulite
  2. Local fat deposits - xanthelasma, lipoma[1]
  3. Alopecia
  4. Rejuvenation - wrinkles, skin tightening
  5. Hyperpigmentation and melasma
  6. Body contouring[2]


Products commonly used in mesotherapy

  1. Phosphatidyl choline- dissolves fat[3],[4]
  2. Organic silicuim - increases collagen production
  3. CRP 1000 - has cytokines for cellular stimulation and copper peptide which improves collagen and elastin sysnthesis
  4. Hyaluronic acid- improves hydration
  5. Following chemicals act as antioxidants and are claimed to decrease pigmentation:

    • Glutathione
    • Ascorbic acid
    • Glycolic acid
    • Pyruvate


  6. Following chemicals are claimed to stimulate hair growth:

    • Buflomedial
    • Minoxidil
    • Finasteride


  7. Vitamins

          i. Vitamin C is used for hyperpigmenation and melasma. It acts as an antioxidant and helps in collagen and elastin production.

          ii. Vitamin A is used in antiaging treatment to improve fine lines and

          iii. Biotin is used in the treatment of alopecia.
  8. Minerals like copper peptide are used for increasing the skin elasticity.


Contraindications

Contraindications to mesotherapy include:

  • Pregnancy
  • Insulin-dependent diabetes
  • History of strokes
  • History of recent cancer
  • Thromboembolic phenomena
  • Patients on medications like aspirin, warfarin, heparin etc.


Materials required for undertaking this therapy include:

  • Mesotherapy products
  • Mesogun [Figure - 1]
  • Mesoneedles (30 G. 12 mm needles)


Techniques of injections

Mesotherapy involves injecting microquanities of medicine in the right place, using one of the following techniques [Table - 1]

  • Intra-epidermal
  • Papular
  • Nappage
  • Point-by-point


Intra-epidermal technique involves placing small quantities of the medicine within the epidermis. It is simple, painless and there is no bleeding. This technique is useful for patients with low pain threshold and is ideal for facial rejuvenation.

Papular technique involves injecting the medicine at the dermoepidermal junction. It is useful for treatment of wrinkles and alopecia. This is the technique used for mesobotox.

Nappage - Here injections are given at a depth of 2- 4 mm at an angle of 30-60°. It is used mainly on the scalp and in the treatment of cellulite.

Point-by-point - This is a precise single injection into the deep dermis. It is used mainly for fat reduction.

Treatment protocol

Usually, mesotherapy treatments are given initially as once per week for four weeks, once every two weeks for two months and once per month for one to two months to achieve best results.

Adverse effects

Adverse effects are common and depend on the product used

  • Bruising and edema are common due to the inflammatory response provoked by some of the chemicals used in mesotherapy.
  • Skin necrosis can occur due to the irritant effect of the chemicals used.
  • Liver toxicity and demyelination of nerves have been reported with large doses of phosphatidyl choline.
  • Atypical mycobacterial infections is a rare side effect.[5] Following mesotherapy there have been reports of atypical mycobacterial infections at sites of injections necessitating antimycobacterial therapy.


Needle-less mesotherapy

This is a newer technique which delivers the mesotherapy products by using ultrasound and/ or iontophoresis. Although it is less traumatic and painless the efficacy of this treatment is only 20% compared to traditional mesotherapy. It may be an option if patients insist on a painless procedure.

Controversial aspects

Since the scientific basis of mesotherapy is not established there is a lot of controversy regarding mesotherapy. The products used here are a combination of herbal and allopathic medicines, the mechanism of action of which is either unknown or doubtful. There are no well-controlled studies to prove the efficacy of this treatment. It is not yet approved by the US FDA and scientific data to support its efficacy is lacking. Adverse effects have been reported with some of the chemicals used in this therapy and there are no clear-cut guidelines on the dosage and efficacy of these products. However, scientific data is likely to evolve with the continued use of these products. Until such time the use of this technique will probably remain a subject of controversy.


  Conclusion Top


Although mesotherapy sounds like a new technique in dermatology, dermatologists have been using similar injection techniques to treat keloids and hypertrophic scars with steroids. The misuse of mesotherapy products in an unsafe manner has even led to the ban of these products in some countries. Therefore caution should be exercised while selecting the right and safe products. Products whose mechanism of action is well understood and whose adverse effects and doses are well studied should be chosen.

Despite the boom in mesotherapy in the West, we must remember that mesotherapy is a controversial therapy at the moment and that it is still in its infancy. More controlled and published studies in the literature are awaited for dermatologists to decide the future of this technique in their practice. Additional clinical and experimental studies are necessary to establish the safety and efficacy of this treatment.

 
  References Top

1.Rotunda AM, Suzuki H, Moy RL, Kolodney MS. Detergent effects of sodium deoxycholate are a major feature of an injectable phosphatidyl choline formulation used for localized fat dissolution. Dermatol Surg 2004;30:1001-8.  Back to cited text no. 1  [PUBMED]  [FULLTEXT]
2.Matarasso A, Pfeifer TM; Plastic Surgery Educational Foundation DATA Committee. Mesotherapy for body contouring. Plast Reconstr Surg 2005;115:1420-4.  Back to cited text no. 2  [PUBMED]  [FULLTEXT]
3.Rose PT, Morgan M. Histological changes associated with mesotherapy for fat dissolution. J Cosmet Laser Ther 2005;7:17-9.  Back to cited text no. 3  [PUBMED]  [FULLTEXT]
4.Mathew M. Avram cellulite: A review of its physiology and treatment. J Cosmet Laser Ther 2005;7:18.  Back to cited text no. 4    
5.Nagore E, Ramos P, Botella Estrada R, Ramos-Niguez JA, Sanmritan O, Castejon P. Cutaneous infection with Mycobacterium fortuitum after localized microinjections (Mesotherapy) treated successfully with a triple drug regimen. Acta Derm Venreol 2001;81:291-3.  Back to cited text no. 5    


    Figures

[Figure - 1]

    Tables

[Table - 1]

This article has been cited by
1 Efficacy of glutathione mesotherapy in burns: an experimental study
A. Buz,T. Görgülü,A. Olgun,E. Kargi
European Journal of Trauma and Emergency Surgery. 2015;
[Pubmed] | [DOI]
2 Minimally invasive facial rejuvenation: current concepts and future expectations
Moetaz El-Domyati,Walid Medhat
Expert Review of Dermatology. 2013; 8(5): 565
[Pubmed] | [DOI]
3 Mesotherapy using dutasteride-containing preparation in treatment of female pattern hair loss: photographic, morphometric and ultrustructural evaluation : Mesotherapy in female pattern hair loss
N. Moftah, N. Moftah, G. Abd-Elaziz, N. Ahmed, Y. Hamed, B. Ghannam, M. Ibrahim
Journal of the European Academy of Dermatology and Venereology. 2012; : no
[VIEW] | [DOI]
4 The Latest Advance in Hair Regeneration Therapy Using Proteins Secreted by Adipose-Derived Stem Cells
Hirotaro Fukuoka,Hirotaka Suga,Keigo Narita,Rei Watanabe,Satoru Shintani
American Journal of Cosmetic Surgery. 2012; 29(4): 273
[Pubmed] | [DOI]
5 Efficacy of mesotherapy in facial rejuvenation: a histological and immunohistochemical evaluation
Moetaz El-Domyati,Tarek S. El-Ammawi,Osama Moawad,Hasan El-Fakahany,Walid Medhat,M? G. Mahoney,Jouni Uitto
International Journal of Dermatology. 2012; 51(8): 913
[Pubmed] | [DOI]
6 Mesotherapy: A bibliographical review | [Mesoterapia: Uma revisão bibliográfica]
Herreros, F.O.C., de Moraes, A.M., Velho, P.E.N.F.
Anais Brasileiros de Dermatologia. 2011; 86(1): 96-101
[Pubmed]
7 Safety of subcutaneous microinjections (mesotherapy) in musicians
Narvarte, D.A., Rosset-Llobet, J.
Medical Problems of Performing Artists. 2011; 26(2): 79-83
[Pubmed]
8 Mesotherapy, definition, rationale and clinical role: A consensus report from the Italian Society of Mesotherapy
Mammucari, M., Gatti, A., Maggiori, S., Bartoletti, C.A., Sabato, A.F.
European Review for Medical and Pharmacological Sciences. 2011; 15(6): 682-694
[Pubmed]
9 Position paper on mesotherapy
Sarkar, R., Garg, V.K., Mysore, V.
Indian Journal of Dermatology, Venereology and Leprology. 2011; 77(2): 232-237
[Pubmed]
10 Hair mesotherapy in treatment of alopecia | [Saç mezoterapisinin alopesi tedavisindeki yeri]
Özdoǧan, S., Erdal, M., Oktar, F.D., Tan, S.
Journal of Clinical and Analytical Medicine. 2011; 2(1): 5-8
[Pubmed]
11 Evaluation of mesotherapeutic injections of three different combinations of lipolytic agents for body contouring
Zekayi Kutlubay
Journal of Cosmetic and Laser Therapy. 2011; : 1
[VIEW] | [DOI]
12 Hair Regenerated therapy with growth factors in adipose-derived stem cells secreted protein
Fukuoka, H., Suse, T., Ohkubo, F.
Japanese Journal of Plastic Surgery. 2010; 53(10): 1095-1104
[Pubmed]
13 A pilot study on lipolytic effect of subcutaneous botulinum toxin injection in rabbits
Bagheri, M., Jahromi, B.M., Bagheri, M., Haghighi, A.B., Noorafshan, A., Kumar, P.V., Omrani, G.R.
Analytical and Quantitative Cytology and Histology. 2010; 32(4): 186-191
[Pubmed]
14 Ischemic colitis after mesotherapy combined with anti-obesity medications
Kim, J.B., Moon, W., Park, S.J., Park, M.I., Kim, K.-J., Lee, J.N., Kang, S.J., Chang, H.K.
World Journal of Gastroenterology. 2010; 16(12): 1537-1540
[Pubmed]
15 Letter: Mesotherapy-Induced Urticaria : LETTER TO THE EDITOR
EFSTATHIOS RALLIS, STEPHANOS KINTZOGLOU, VASSILIKI MOUSSATOU, PANAGIOTA RIGA
Dermatologic Surgery. 2010; 36(8): 1355
[VIEW] | [DOI]
16 Alopecia secondary to mesotherapy
Duque-Estrada, B., Vincenzi, C., Misciali, C., Tosti, A.
Journal of the American Academy of Dermatology. 2009; 61(4): 707-709
[Pubmed]
17 Cervical lymphoadenopathy due to Pseudomonas aeruginosa following mesotherapy | [Linfoadenopatia cervicale da Pseudomonas aeruginosa dopo trattamento con mesoterapia]
Shaladi, A.M., Crestani, F., Bocchi, A., Saltari, M.R., Piva, B., Tartari, S.
Infezioni in Medicina. 2009; 17(3): 169-172
[Pubmed]
18 Cutaneous Granulomatous Reaction from Mesotherapy
Gonca Gokdemir,Asli Küçükünal,Damlanur Sakiz
Dermatologic Surgery. 2009; 35(2): 291
[Pubmed] | [DOI]
19 Alopecia secondary to mesotherapy
Bruna Duque-Estrada,Colombina Vincenzi,Cosimo Misciali,Antonella Tosti
Journal of the American Academy of Dermatology. 2009; 61(4): 707
[Pubmed] | [DOI]
20 Cutaneous granulomatous reaction from mesotherapy
Gokdemir, G., Küçükünal, A., Sakiz, D.
Dermatologic Surgery. 2009; 35(2): 291-293
[Pubmed]
21 Cosmetic mesotherapy: Between scientific evidence, science fiction, and lucrative business
Atiyeh, B.S., Ibrahim, A.E., Dibo, S.A.
Aesthetic Plastic Surgery. 2008; 32(6): 842-849
[Pubmed]
22 Delirium with psychotic features possibly associated with mesotherapy
Tor, P.-C., Lee, T.-S.
Psychosomatics. 2008; 49(3): 273-274
[Pubmed]
23 Cosmetic Mesotherapy: Between Scientific Evidence, Science Fiction, and Lucrative Business
Bishara S. Atiyeh,Amir E. Ibrahim,Saad A. Dibo
Aesthetic Plastic Surgery. 2008; 32(6): 842
[Pubmed] | [DOI]
24 Delirium With Psychotic Features Possibly Associated With Mesotherapy
Phern-Chern Tor,Tih-Shih Lee
Psychosomatics. 2008; 49(3): 273
[Pubmed] | [DOI]



 

Top
Print this article  Email this article
Previous article Next article

    

Online since 15th March '04
Published by Wolters Kluwer - Medknow