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 CASE REPORT
Year : 2006  |  Volume : 72  |  Issue : 5  |  Page : 367--369

Leg ulcers due to hyperhomocysteinemia


Department of Dermatology, Manipal Hospital, Bangalore, Karnataka, India

Correspondence Address:
D S Krupa Shankar
Department of Dermatology, Manipal Hospital, 98 Rustom Bagh, Airport Road, Bangalore-560 017, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0378-6323.27755

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Chronic leg ulcers are rare in young adults and generally indicate a vascular cause. We report a case of a 26-year-old man with leg ulcers of eight months duration. Doppler study indicated venous incompetence and a postphlebitic limb. However, as the distribution and number of ulcers was not consistent with stasis alone and no features of collagen vascular disease were noted, a hyperviscosity state was considered and confirmed with significantly elevated homocysteine level in the serum. Administration of vitamins B1, B2, B6 and B12, trimethyl-glycine, mecobalamine, folic acid and povidone iodine dressings with culture-directed antibiotic therapy led to a satisfactory healing of ulcers over a period of one month. Hyperhomocysteinemia must be considered in the differential diagnosis of leg ulcers in young individuals.






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Online since 15th March '04
Published by Wolters Kluwer - Medknow