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 ORIGINAL ARTICLE
Year : 2006  |  Volume : 72  |  Issue : 4  |  Page : 266--269

The efficacy of 1% metronidazole gel in facial seborrheic dermatitis: A double blind study


1 Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Dermatology, Isfahan Medical School, Isfahan University of Medical Sciences and Health services, Isfahan, Iran
3 Department of Pharmaceutics, Isfahan Pharmacy School, Isfahan University of Medical Sciences and Health services, Isfahan, Iran
4 Isfahan University of Medical Sciences, Isfahan, Iran

Correspondence Address:
Amir H Siadat
Skin Diseases and Leishmaniasis Research Center, Sedigehe Tahereh Recearch Center, Isfahan University of Medical Sciences, Isfahan
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0378-6323.26745

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Background: Seborrheic dermatitis is a common, chronic inflammatory disease of the skin, characterized by erythematous plaques that are covered with yellow, greasy, scales and may or may not be associated with itching. Although a few studies have suggested use of topical metronidazole for the treatment of seborrheic dermatitis, there is no general consensus about it. Aims: To evaluate the efficacy of 1% metronidazole gel and its vehicle alone, in the treatment of seborrheic dermatitis. Methods: This was a double-blind, prospective, clinical trial. Fifty six patients with seborrheic dermatitis were randomly allocated to either apply 1% metronidazole gel or placebo to their facial lesions, twice daily for 8 weeks. All the patients were evaluated and scored every 2 weeks for 8 weeks. The results were analyzed statistically. Results: A total of 56 patients entered this study and 53 patients completed the treatment course. There was no significant difference in terms of demographic data and lesions severity score. There were statistically significant differences in the reduction of mean severity scores between the 2 groups at the second, fourth, sixth and eighth weeks of treatment ( p < 0.05). Metronidazole gel significantly decreased mean of seborrheic dermatitis severity score from the 2nd visit ( p <0.001). Conclusion: Metronidazole gel is an effective treatment for facial seborrheic dermatitis.






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