Indexed with PubMed and Science Citation Index (E) 
Users online: 2964 
     Home | Feedback | Login 
About Current Issue Archive Ahead of print Search Instructions Online Submission Subscribe What's New Contact  
    Next article
    Previous article
    Table of Contents

    Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
  Related articles
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded1400    
    Comments [Add]    
    Cited by others 3    

Recommend this journal


Year : 2006  |  Volume : 72  |  Issue : 1  |  Page : 8--18

AIDS vaccine: Present status and future challenges

Department of Dermatology and Venereology, Pt. JNM Medical College and associated Dr. BRAM Hospital, Raipur, Chattisgarh, India

Correspondence Address:
P K Nigam
Department of Dermatology and Venereology, Pt. JNM Medical College and associated Dr. BRAM Hospital, Raipur, Chattisgarh 492001
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0378-6323.19711

Rights and Permissions

Development of a preventive vaccine for HIV is the best hope of controlling the AIDS pandemic. HIV has, however, proved a difficult pathogen to vaccinate against because of its very high mutation rate and capability to escape immune responses. Neutralizing antibodies that can neutralize diverse field strains have so far proved difficult to induce. Adjuvanting these vaccines with cytokine plasmids and a "prime-boost," approach is being evaluated in an effort to induce both CTL and antibody responses and thereby have immune responses active against both infected cells and free viral particles, thereby necessitating fewer doses of recombinant protein to reach maximum antibodies titers. Although obstacles exist in evaluation of candidate HIV vaccines, evidence from natural history studies, new molecular tools in virology and immunology, new adjuvants, new gene expression systems, new antigen delivery systems, recent discoveries in HIV entry and pathogenesis, and promising studies of candidate vaccines in animal models have provided reasons to hope that developing a safe and effective AIDS vaccine is possible and within reach.


Print this article     Email this article

Online since 15th March '04
Published by Wolters Kluwer - Medknow