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 ORIGINAL ARTICLE
Year : 2006  |  Volume : 72  |  Issue : 1  |  Page : 33--36

Comparison of the efficacy of topical 1% lindane vs 5% permethrin in scabies: A randomized, double-blind study


1 Departments of Dermatology ,Guilan University of Medical Sciences, Rasht, Iran
2 Departments of Pharmacology, Guilan University of Medical Sciences, Rasht, Iran
3 Department of Pharmacology, Tehran University of Medical Sciences, Tehran, Iran

Correspondence Address:
Omid Zargari
Hafez Street, Booali Building, Rasht 41378
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0378-6323.19715

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Background: Permethrin, a pyrethroid insecticide, is not yet available in Iran and may be a useful substitute for the control of scabies in Iran. Aim: To compare the efficacy of topical lindane with topical permethrin in the treatment of scabies in a population in Iran. Methods: In a double-blind, randomized study, all consecutive patients with scabies were randomized into two groups. One group and their family contacts received 1% lindane cream, and the other group and their family contacts were treated with topical 5% permethrin cream. Subsequently, patients were followed up at 2- and 4-week post-treatment. Results: Of the 99 patients enrolled in the study, 47 patients received 1% lindane cream, and 52 patients were treated topically with 5% permethrin cream. Permethrin provided an improvement rate of 84.6% after two weeks, whereas lindane was effective only in 48.9% of patients. Conclusion: Permethrin (5%) cream was found to be significantly more effective in the treatment of scabies in comparison with lindane in this study, and it seems that it could be an alternative treatment.






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