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   Abstract
   Introduction
   Senile changes i...
   Nail disorders a...
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REVIEW ARTICLES
Year : 2005  |  Volume : 71  |  Issue : 6  |  Page : 386-392

Nail changes and disorders among the elderly


Department of Dermatology and STD, Sri Devaraj Urs Medical College, Tamaka, Kolar, India

Correspondence Address:
Gurcharan Singh
108 A, Jal Vayu Vihar, Kammanhalli, Bangalore-560043
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0378-6323.18941

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  Abstract 

Nail disorders are frequent among the geriatric population. This is due in part to the impaired circulation and in particular, susceptibility of the senile nail to fungal infections, faulty biomechanics, neoplasms, concurrent dermatological or systemic diseases, and related treatments. With aging, the rate of growth, color, contour, surface, thickness, chemical composition and histology of the nail unit change. Age associated disorders include brittle nails, trachyonychia, onychauxis, pachyonychia, onychogryphosis, onychophosis, onychoclavus, onychocryptosis, onycholysis, infections, infestations, splinter hemorrhages, subungual hematoma, subungual exostosis and malignancies. Awareness of the symptoms, signs and treatment options for these changes and disorders will enable us to assess and manage the conditions involving the nails of this large and growing segment of the population in a better way.


Keywords: Nail changes, Nail disorders, Geriatric


How to cite this article:
Singh G, Haneef NS, Uday. Nail changes and disorders among the elderly. Indian J Dermatol Venereol Leprol 2005;71:386-92

How to cite this URL:
Singh G, Haneef NS, Uday. Nail changes and disorders among the elderly. Indian J Dermatol Venereol Leprol [serial online] 2005 [cited 2017 Jul 27];71:386-92. Available from: http://www.ijdvl.com/text.asp?2005/71/6/386/18941



  Introduction Top


Nail disorders comprise approximately 10% of all dermatological conditions and affect a high percentage of the elderly.[1] Various changes and disorders are seen in the aging nail, many of which are extremely painful, affecting stability, ambulation and other functions. The prevention and management of these conditions require periodic cutting of the nails and appropriate medical care. Unfortunately, these are difficult for the elderly because of thickness of the nails, difficulty in accessing the feet, poor vision and sometimes, lack of motivation for personal care. This article reviews the age associated nail changes and disorders along with related management.


  Senile changes in nails Top


The senile changes in the nails are thought to result from impaired peripheral circulation, commonly due to arteriosclerosis.[2] Though nail plate is an efficient sunscreen,[3],[4] UV radiation may play a role in such changes. Trauma, faulty biomechanics, infections, concurrent dermatological or systemic diseases and their treatments are also contributory factors.[5],[6] The following changes are observed in human nails as part of the aging process:

a) Alteration in chemical composition

The calcium and iron contents of the aging nails are increased and decreased respectively.[2]

b) Alteration in histology

The nail plate keratinocytes are increased in size, with increased number of 'pertinax bodies,' which are remnants of keratinocyte nuclei. The nail bed dermis shows thickening of the blood vessels and degeneration of the elastic tissue, especially beneath the pink part of the nail.[7]

c) Alteration in nail growth

Fingernails and toenails grow at an average rate of 0.1 mm/day (3.0 mm/month) and 0.03 mm/day (1.0 mm/month) respectively.[7] In the elderly, the rate of nail growth decreases by approximately 0.5%/year between 25 to 100 years of age.[8]

As observed by Oreintreich and Scharp (1967),[2] thumbnail growth decreases on an average by 38% between the third and the ninth decade. In this study, the decrease in growth of nails in females was greater up to the sixth decade; thereafter no change was observed till the eighth decade, whereas in males, the slowing was more pronounced from the sixth to the eighth decade.[2]

d) Alteration in nail color

Senile nails may appear pale, dull, and opaque, with the color ranging from white (leuconychia) or yellow to brown or grey.[7] Leuconychia may be true (due to matrix involvement), which may be total, subtotal, transverse, punctate or longitudinal; pseudoleu-conychia (of exogenous origin), seen in onychomycosis, and keratin granulations after nail enamel application; and apparent leuconychia (due to changes in the underlying tissue).

The clinical presentations are varied like

i) Terry's nails: The nails are colored white proximally and have a distal normal pink band of 0.5-3 mm width. These are seen in seen in cirrhosis of the liver, chronic congestive heart failure, adult-onset diabetes mellitus and malnutrition.

ii) Half and half nails of Lindsay: Seen in uremic patients, the nails have a proximal dull white area with the distal 20-60% portion brownish.[9]

iii) Muehrcke's paired, narrow white bands: The bands are present parallel to the lunula. This is seen in hypoalbuminemia (less than 2.2g/100ml),[10] nephrotic syndrome, glomerulonephritis, malnutrition, acrodermatitis enteropathica[10] or following chemotherapy.[11]

iv) The lunula may be decreased or absent altogether.[12],[13]

v) Neapolitan nails, which can be seen in up to 20% of the persons older than 70 years, are characterized by three bands similar to the colors of Neapolitan ice-cream, i.e. a proximal white portion with absent lunula, a central normal pink band and an opaque distal free edge.[14]

e) Alteration in contour

Senile nails usually have an increased transverse curvature and a decreased longitudinal curvature. Flattening of the nail plate (platyonychia), spooning (koilonychia), and pincer nail deformity (involution), are found more frequently.[8],[15]

f) Alteration in surface texture

Normally, the nails have a smooth surface. The senile nail may have increased longitudinal striations due to altered turnover rate of the matrix cells. The striations are termed "onychorrhexis" if they are superficial and "ridges" or "sausage-link ridges" or "beading" if deep.[7],[8] Aging is the commonest cause of onychorrhexis.[10] Beau's lines (transverse ridges) and pitting are also found frequently.[16] The nails may be rough (trachyonychia) with splitting and fissuring.

g) Alteration in thickness

Fingernails have a normal average thickness of 0.6 mm in males and 0.5 mm in females. Toenails are thicker, 1.65 ±0.43 mm and 1.38±0.2 mm in males and females respectively.[17] The nail plates of the thumb and great toe are the thickest, whereas the little finger has the thinnest nail plate. In the elderly, the nail plate thickness may increase, decrease or may remain unchanged.[7],[8]


  Nail disorders among the elderly Top


a) Brittle nails (Fragilitas unguium)

The nail plate hardness is dependent on its state of hydration, the normal water content being 18% (10-30%). Nails become brittle when the water content is less than 16% and become soft when it is above 25%.[7] In persons older than 60 years, brittle nails are common, manifesting as excessive longitudinal ridges, roughness of the nail plate (trachyonychia), horizontal lamellar splitting of the distal nail plate (onychoschizia), and/or irregularity of the distal edge of the nail plate (Castle battlement appearance).[5],[18],[19]

Repeated cycles of hydration and dehydration, as occur in excessive domestic wet work or overuse of dehydrating agents like nail enamels, nail enamel removers and cuticle removers, may precipitate brittle nails.[5],[18],[20] The first three fingers of the dominant hand are particularly susceptible.[18]

After elimination of the exacerbating factors, local measures should be undertaken to re-hydrate the nail plate, cuticle and the nail folds. This can be achieved by soaking the nails in lukewarm water for 10 to 20 minutes, followed by application of moisturizers such as lactic acid, urea, phospholipids or mineral oils, preferably under occlusion (cotton gloves or socks).[5] Oral biotin, iron, thiamine, cysteine, pantothenic acid, PABA, have been found to be effective.[6],[21],[22] In intractable cases, formaldehyde containing nail enamels can be helpful, which should be removed and reapplied not more than once a week.[5]

b) Clubbing (Hippocratic nails/watch glass nails)

Digital clubbing is said to be present if the angle between the normal nail plate and the skin of the finger at the proximal nail fold (Lovibond's angle) is less than 180°, usually close to 160°.[23]

Bilateral clubbing occurs generally (80%) due to cardiopulmonary disease. Disorders of the liver, gastrointestinal tract and kidney may also present with bilateral digital clubbing. Endocarditis, congestive heart failure, cirrhosis of the liver, ulcerative colitis and chronic pyelonephritis are the conditions commonly associated. Unilateral clubbing is seen in lymphadenitis, Pancoast tumor of the lungs and erythromelalgia. Uni-digital clubbing occurs in vascular lesions of the same extremity like an aneurysm, arteriovenous fistula or peripheral shunt.[23] The syndrome of acquired hypertrophic pulmonary osteoarthropathy is a combination of clubbing, muscle weakness, joint pains, and swelling and hypertrophy of the upper and lower extremities. There is associated soft tissue proliferation, bone pain, proliferative periostitis and peripheral neurovascular disease. This condition occurs in association with a malignant thoracic tumor, especially bronchogenic carcinoma.[23]

c) Onychodystrophies from faulty biomechanics and trauma

Bony deformities of the digits or foot-to-shoe incompatibility can cause faulty biomechanics leading to onychodystrophies such as nail plate hypertrophy (onychauxis), subungual corn (onychoclavus), ingrowing toe nails (onychocryptosis), onychogryphosis, onycholysis, subungual hematoma and subungual hyperkeratosis.[5],[7]

Treatment should address the underlying bony deformity, foot care and appropriate footwear. Velcro shoes are convenient for the elderly. A molded shoe or an orthotic insert helps in non-surgical management of bony deformities.[5],[7]

d) Infections/Infestations

The nail apparatus may get primarily infected or involved in infections of the adjacent structures.

Generally, onychomycosis is the commonest nail infection, accounting for 40% of all onychopathies and 30% of all cutaneous fungal infections.[24] The prevalence of onychomycosis increases with age, reaching nearly 20% in patients over 60 years.[25] It is especially common in the elderly, often involving both toenails and fingernails. The great toenail is the commonest one involved. The subtypes of onychomycosis are distal subungual onychomycosis (DSO, the commonest type), proximal subungual onychomycosis (PSO), white superficial onychomycosis (WSO) and candidal onychomycosis. The first three types are usually caused by dermatophytes such as Trichophyton rubrum and Trichophyton mentagrophytes . Non-dermatophyte molds, such as Scopulariopsis brevicaulis , Hendersonula toruloidea and Scytalidium hyalinum, are found more frequently in the elderly.[5]

In view of the prolonged duration of therapy, multiple drug interactions and side effects associated with the use of systemic therapies with griseofulvin and ketoconazole, topical antifungal therapy (e.g., ciclopirox lacquer)[26] is preferred in the elderly, although it provides only partial and symptomatic relief.[5] Short duration therapy or pulse therapy with itraconazole, terbinafine or fluconazole can be tried.[24] Terbinafine is the most preferred drug because of its superior mycologic cure rates and fewer drug interactions.[25] Nail avulsion can be employed for severe disease affecting only one or two nails.[5],[7],[27]

Paronychia (infection/inflammation of the nail fold) can be acute or chronic. Acute paronychia is a bacterial infection of the nail folds, usually caused by Staphylococcus aureus or Pseudomonas species. Most cases are trauma induced and involve only one nail.[24] Treatment is similar to that of other bacterial infections of the skin and involves draining of the abscess, warm saline soaks, systemic antibiotics and topical antibiotics such as 2% mupirocin ointment.[5],[24] Severe infections, particularly those caused by Pseudomonas , may warrant nail avulsion.

Chronic paronychia, caused by c andida species or gram negative bacteria ( Proteus sp. or Klebsiella sp.), appears as red, swollen, boggy, tender nail folds with loss of cuticle and a patent proximal nail groove. Multiple transverse ridges may be seen in the nail plate.[5],[24] Treatment is prolonged and includes keeping the nail folds and the surrounding skin dry, application of a topical antifungal or a topical antiseptic such as 4% thymol in alcohol and if necessary, excision of the chronic hypertrophic proximal nail fold. In cases with severe inflammation, topical or intra-lesional steroids can be used.[5],[24]

Sarcoptes scabiei may inhabit the subungual hyperkeratotic debris, leading to persistent infestations or epidemics of scabies. The nails should be cut short and fingertips should be brushed with a scabicide in affected patients.[5]

Periungual warts are due to infection with human papilloma virus. These occur especially in persons receiving immunosuppressive therapy.[5],[7]

The nails can be involved in leprosy, (93% in multibacillary vs 57% in paucibacillary), leading to dry, lusterless, narrow, shrunken nails with longitudinal ridging and subungual hyperkeratosis.[28] Onychomycosis occurs in 32% of these patients.[29] Clofazimine causes pigmentation of the nails.[29]

Nail changes in syphilis include dullness, brittleness, pitting, splitting (onyxis craquelι), onycholysis, elkonyxis, shedding, distortion, Beau's lines in secondary syphilis, and amber coloured nails, and paronychia in tertiary syphilis.[1],[30],[31]

e) Onychauxis/Pachyonychia

Onychauxis (localized hypertrophy of the nail plate) manifests as hyperkeratosis, discoloration, and loss of translucency of the nail plate, with or without subungual hyperkeratosis.[7] This may be complicated by distal onycholysis, pain, increased susceptibility for onychomycosis, subungual hemorrhage and subungual ulceration.[7]

Periodic partial or total debridement of the thickened nail should be done with the help of electric drills or burrs. Chemical (40% urea paste) or surgical avulsion may be needed. Permanent ablation with chemical (phenol) or surgical matricectomy may be required for recurrent and troublesome onychauxis.[5],[7],[32]

f) Onychogryphosis

This refers to enlargement and thickening of the nail plate, which appears "ram's horn-like" or "oyster-like", mostly involving the great toenail. The nail plate appears uneven, thickened and brown to opaque, often with multiple transverse striations and hypertrophy of the underlying nail bed. This is mainly due to infrequent cutting of the nails. Other etiologies include trauma, hypertrophy of the nail bed and bony deformities like hallux valgus.[5],[7] The nail plate initially grows upwards and thereafter deviates laterally towards the other toes, the direction of growth being influenced by pressure from footwear and matrix activity. A few patients develop subungual gangrene due to pressure effects, especially in the presence of diabetes mellitus or peripheral vascular disease.[5],[18]

In hemi-onychogryphosis, a condition mimicking onychogryphosis, the nail plate grows laterally from the beginning. This may be a complication of persistent congenital malalignment of the great toenails. This condition can be prevented by regular nail plate trimming and foot care.[5],[18]

Treatment is required for cosmetic reasons and for complications like subungual gangrene. Conservative management is by filing the nail plate with an electric drill or burr with removal of subungual hyperkeratosis, and subsequent periodic trimming of the nail plate. Surgical or chemical nail avulsion, with or without matricectomy, can be employed in persons with a good vascular supply.[5],[7]

g) Onychophosis

This refers to localized or diffuse hyperkeratosis on the lateral or proximal nail folds, in the space between the nail folds and nail plate, and also subungually. It results from repeated minor trauma, and nail fold and adjacent soft tissue deformities such as nail fold hypertrophy, onychomycosis, onychocryptosis, xerosis, etc. The first and the fifth toes are commonly affected.[5],[7]

Onychophosis can be prevented by the use of appropriate footwear to minimize pressure effects. It is treated by debridement of the hyperkeratotic tissue by means of keratolytics (urea 20%, lactic acid 12% or salicylic acid 6-20%), followed by application of emollients, thinning of the nail plate, packing of the nail and, if necessary, surgery.[5],[7]

h) Onychoclavus (Subungual heloma/corn)

It is a hyperkeratotic process in the nail area, mostly under the distal nail margins, due to a bony deformity or abnormal foot function. It should be differentiated from subungual melanoma, subungual exostosis, a foreign body or an epidermoid cyst.[5],[7] It can be enucleated by removing the corresponding section of the nail plate with excision of the hyperkeratotic tissue. Any bony abnormality should be corrected and modified footwear, protective pads or tube foam should be used to prevent recurrence.[5],[7]

i) Onychocryptosis (Ingrown nails)

This condition results when part of the nail plate pierces the lateral nailfold. Three major types are known: over-curvature of the nail plate (pincer nail), subcutaneous ingrowing toenail and hypertrophy of the lateral nail fold. Clinically, it manifests as inflammation of the nail fold, often with granulation tissue formation, sepsis, pain and tenderness of the involved digit.[5],[7]

The causes include improper cutting of the nails, external pressure due to ill-fitting footwear, long toes and other deformities, hyperhidrosis, poor foot hygiene, prominent nail folds, and presence of a spicule.[5],[7] In the elderly with impaired arterial circulation and sensation, infection and gangrene may supervene.[5],[7]

Predisposing factors should be corrected. Any offending spicule should be removed.[15] The distal nail plate should be cut straight across, so that the curves of the nail plate are beyond the distal edge of the lateral nail folds. Placing a small wisp of cotton beneath the lateral free edge of the nail plate prevents ingrowing.[5],[7] Warm soaks, topical and systemic antibiotics, with application of a silver nitrate stick or curettage to remove granulation tissue, can be done.[16] In severe and intractable cases, complete or partial avulsion of the ingrown nail and excision of the involved adjacent tissue (nail folds/nail bed) can be done.[6] Other options are partial (lateral) matricectomy with phenol, stainless steel wire nail brace (orthonyx technique), and cryotherapy.

j) Onycholysis

Separation of the nail plate from the nail bed beginning distally and progressing to the proximal end may be idiopathic or due to trauma, impaired circulation.[16]

k) Onychoatrophia

This condition presents as dystrophic fingernails and toenails showing triangular residual nail plates. This occurs as a component of Cronkhite-Canada syndrome (alopecia, nail defects and polyposis of the gastrointestinal tract).[33]

l) Splinter hemorrhages and subungual hematomas

Splinter hemorrhages, which are most commonly traumatic in the elderly, are black and located in the middle or distal third of the fingernail. In contrast, splinter hemorrhages induced by systemic disorders are red in color and proximal in location.[5],[7]

Subungual hematomas, which are also traumatic, are red and painful when of recent onset, and dark blue and non-tender when old. Characteristically, these are carried forward with the growth of the nail, unlike a pigmented lesion of the nail matrix or nail bed.[5],[7] In a few patients, distal onycholysis with eventual auto-avulsion of the nail plate can occur. Acute lesions should be drained to relieve pressure, by piercing the nail plate with a needle or electric drill. In chronic cases, melanoma should be ruled out.[5],[7]

m) Nail changes in some skin diseases

Nail involvement is very common in psoriasis and consists of pitting, onycholysis, discoloration (yellow or green) and thickening. Although psoriasis is the most common condition producing pitting, nail pits may also be seen in alopecia areata, eczema involving the digits, fungal infections and erythroderma.[16]

n) Neoplastic nail conditions

Subungual exostosis is a benign, tender, nodular, hyperkeratotic bony proliferation most commonly involving the medial side of the great toe. This is associated with onychodystrophy/onychoclavus of the overlying nail.[34] Trauma and faulty biomechanics are the commonest causes in the elderly. It manifests as an inverted 'U' shaped nail plate due to hypertrophic nail bed, often with accentuation of the dorsal interphalangeal joint skin crease and onychocryptosis. It may lead to pincer nail deformity.[2],[5] Treatment is by aseptic removal of the excess bone after radiographic confirmation.[2],[5]

Myxoid pseudocysts (mucous cysts or periungual ganglion) are probably the commonest benign tumors. They are commoner in females and usually involve the proximal nail fold of fingers. These are asymptomatic, soft to firm, cystic/fluctuant, sometimes causing transverse nail depressions. They can be treated with intralesional injections of triamcinolone or surgical removal.[2]

Subungual melanoma, mostly affecting the great toe, is common in the elderly white population. The peak incidence was in eighth decade in one study.[2] Bowen's disease, squamous cell carcinoma, basal cell carcinoma and glomus tumor are also more frequent in this age group.

o) Adverse effects due to nail cosmetics

Geriatric patients may show nail changes due to prolonged use of nail cosmetics. Nail polish may cause yellow-orange staining, superficial friability ("granulation") and brittleness of the nail plate. Allergic dermatitis due to nail polish can affect sites other than the nail, and also the spouse of the user. Metal pellets in the nail polish bottles may precipitate reactions due to nickel and onycholysis. Acetone containing nail removers cause excessive dryness of the nail plate and paronychia. Sculptured artificial nails (methyl methacrylate), preformed plastic nails and stick on nail dressing may cause onychodystrophy, onycholysis, thinning, splitting and discoloration of the nail, nail fold dermatitis and loss of cuticle. Nail hardeners (formaldehyde) may cause subungual hemorrhage and bluish discoloration of the nail. Cuticle removers may cause irritation. Manicuring instruments may damage the nail.

The nails may also be affected by cosmetics used at other sites like hair removers, hair tonics and bleaching agents.[3]


  Conclusion Top

"The test of any civilization is the measure of consideration and care which it gives to its weaker members".

The elderly, who are one of the more vulnerable sections of our society, show various age related changes and disorders involving the nails. These may result in pain and interfere with their daily activities. The esthetic aspect of the nails is significant even in the elderly, as it may affect social as well as intra-family interactions. Awareness of the clinical conditions affecting nails in the geriatric age group and related management options is essential. This will help in reducing the psychological impact of nail disorders among the aged and improve their quality of life.



 
  References Top

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2.Baran R, Dawber RP. The nail in childhood and old age. In: Baran R, Dawber RPR, editors. Diseases of the nails and their management. 2nd ed. Oxford: Blackwell Science; 1994. p. 81-96.  Back to cited text no. 2      
3.Dawber RPR, Baran R, De Berker D. Disorders of nails. In: Champion RH, Burton JL, Burns DA, Breathnach SM, editors. Rook/ Wikinson/ Ebling Texbook of dermatology. 6th ed. Oxford: Blackwell Science; 1998. p. 2815-68.  Back to cited text no. 3      
4.Parker SG, Diffey BL. The transmission of optical radiation through human nails. Br J Dermatol 1983;108:11-4.  Back to cited text no. 4      
5.Cohen PR, Scher RK. Geriatric nail disorders: diagnosis and treatment. J Am Acad Dermatol 1992;26:521-31.  Back to cited text no. 5      
6.Drake LA, Dinehart SM, Farmer ER, Goltz RW, Graham GF, Hordinsky MK, et al. Guidelines of care for nail disorders. J Am Acad Dermatol 1996;34:529-33.  Back to cited text no. 6      
7.Cohen PR, Scher RK. Aging. In: Hordinsky MK, Sawaya ME, Scher RK, editors. Atlas of hair and nails. Philadelphia: Churchill Livingstone; 2000. p. 213-25.  Back to cited text no. 7      
8.Cohen PR, Scher RK. Nail changes in the elderly. J Geriatric Dermatol 1993;1:45-53.  Back to cited text no. 8      
9.Singh G, Singh SJ, Chakrabarty N, Siddharaju KS, Prakash JC. Cutaneous manifestations of chronic renal failure. Indian J Dermatol Venereol Leprol 1989;55:167-9.  Back to cited text no. 9      
10.Holzberg M. Nail signs of systemic disease. In: Hordinsky MK, Sawaya ME, Scher RK, editors. Atlas of hair and nails. Philadelphia: Churchill Livingstone; 2000. p. 59-70.  Back to cited text no. 10      
11.Baran R, Tosti A. Nails. In: Freedberg IM, Eisen AZ, Wolff K, Austen KF, Goldsmith LA, Katz SI, editors. Fitzpatrick's dermatology in general medicine. 6th ed. New York: McGraw Hill; 2003. p. 656-71.  Back to cited text no. 11      
12.Cohen PR. The lunula. J Am Acad Dermatol 1996;34:943-53.  Back to cited text no. 12      
13.Lewis BL, Montgomery H. The senile nail. J Invest Dermatol 1955;24:11-8.  Back to cited text no. 13      
14.Cohen PR, Scher RK. The nail in older individuals. In: Scher RK, Daniel CR III, editors. Nails: Therapy, diagnosis, surgery. Philadelphia: WB Saunders; 1997. p.127-50.  Back to cited text no. 14      
15.Dawber R, Bristow I, Turner W. Nail Disorders. In: Text atlas of podiatric dermatology. London: Martin Dunitz Ltd; 2001. p. 105-31.  Back to cited text no. 15      
16.Verbow J. Skin diseases in the elderly. London: William Heinemann; 1974.  Back to cited text no. 16      
17.Tosti A, Piraccini BM. Biology of nails. In: Freedberg IM, Eisen AZ, Wolff K, Austen KF, Goldsmith LA, Katz SI, editors. Fitzpatrick's dermatology in general medicine. 6th ed. New York: McGraw Hill; 2003. p. 159-63.  Back to cited text no. 17      
18.Baran R, Dawber RPR. Physical signs. In: Baran R, Dawber RP, editors. Diseases of the nails and their management. 2nd ed. Oxford: Blackwell Science; 1994. p. 35-80.  Back to cited text no. 18      
19.Wallis MS, Bowen WR, Guin JD. Pathogenesis of onychoschizia (lamellar dystrophy). J Am Acad Dermatol 1991;24:44-8.  Back to cited text no. 19      
20.Scher RK. Brittle nails. Int J Dermatol 1989;28:515-6.  Back to cited text no. 20      
21.Hochman LG, Scher RK, Meyerson MS. Brittle nails: response to daily biotin supplementation. Cutis 1993;51:303-5.  Back to cited text no. 21      
22.Colombo VE, Gerber F, Bronhofer M, Floersheim GL. Treatment of brittle fingernails and onychoschizia with biotin: scanning electron microscopy. J Am Acad Dermatol 1990;23:1127-32.  Back to cited text no. 22      
23.Meyerson MS, Scher RK. Nail signs of systemic disease. In: Callen JP, Jorizzo JL, Greer KE, Penneys NS, Piette WW, Zone JJ, editors. Dermatological signs of internal disease. 2nd ed. Philadelphia: WB Saunders Co; 1999. p. 368-75.  Back to cited text no. 23      
24.Rich P. Nail disorders: diagnosis and treatment of infectious, inflammatory and neoplastic nail conditions. Med Clin North Am 1998;82:1171-83.  Back to cited text no. 24      
25.Loo DS. Cutaneous fungal infections in the elderly. Dermatol Clin 2004;22:33-50.  Back to cited text no. 25      
26.Weinberg JW, Vafaie J, Scheinfeld NS. Skin infections in the elderly. Dermatol Clin 2004;22:51-61.  Back to cited text no. 26      
27.Drake LA, Dinehart SM, Farmer ER, Goltz RW, Graham GF, Hordinsky MK, et al. Guidelines of care for superficial mycotic infections of the skin: onychomycosis. J Am Acad Dermatol 1996;34:116-21.  Back to cited text no. 27      
28.Jopling WH, McDougall AC. The disease. In: Handbook of leprosy. 5th ed. New Delhi: CBS Publishers & Distributors; 1996. p. 10-53.  Back to cited text no. 28      
29.Sharma VK. Leprosy: Classification and clinical features. In: Valia RG, Valia AR, editors. IADVL Textbook and atlas of dermatology. 2nd ed. Mumbai: Bhalani Publishing House; 2001. p. 1578-603.  Back to cited text no. 29      
30.King A, Nicol C, Rodin P. Venereal diseases. 4th ed. London: Balliere Tindall; 1980. p.15-43.  Back to cited text no. 30      
31.Misra RS, Kumar J. Syphilis: clinical features and natural course. In: Sharma VK, Bhargava R, Kar HK, Usman N, Sethuraman G, editors. Sexually transmitted diseases and AIDS. New Delhi: Viva Books Pvt Ltd; 2003. p.165-82.  Back to cited text no. 31      
32.Helfand AE. Nail and hyperkeratotic problems in the elderly foot. Am Fam Physic 1989;39:101-10.  Back to cited text no. 32      
33.Weismann K, Graham RM. Systemic disease and the skin. In: Champion RH, Burton JL, Burns DA, Breathnach SM, editors. Rook/ Wikinson/ Ebling Texbook of dermatology. 6th ed. Oxford: Blackwell Science; 1998. p. 2703-57.  Back to cited text no. 33      
34.Salasche SJ, Garland LD. Tumors of the nail. Dermatol Clin 1985;3:521-30.  Back to cited text no. 34      



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2 Nail changes and disorders in elderly Egyptians
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Journal of Cosmetic Dermatology. 2014; 13(4): 269
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3 Geriatría y dermatología: revisión de la literatura
Cristián Navarrete-Dechent,María Constanza del Puerto Troncoso,Ariel Hasson Nisis
Piel. 2013; 28(3): 154
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4 Epidemiological profile of onychomycosis in the elderly living in the nursing homes
T. Gunduz,K. Gunduz,K. Degerli,M.E. Limoncu
European Geriatric Medicine. 2013;
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5 Management of simple brittle nails
Rigopoulos Dimitris,Daniel Ralph
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6 Ram’s horn nails
M. Galeone, F. Scarfì, M. Arunachalam, E. M. Difonzo
Clinical and Experimental Dermatology. 2012; : no
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7 Trachyonychia: A comprehensive review
Gordon, K.A., Vega, J.M., Tosti, A.
Indian Journal of Dermatology, Venereology and Leprology. 2011; 77(6): 640-645
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8 Study of nail changes and nail disorders in the elderly
Rao, S., Banerjee, S., Ghosh, S., Gangopadhyay, D., Jana, S., Mridha, K.
Indian Journal of Dermatology. 2011; 56(5): 603-606
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9 Onychoclavus due to subungual exostosis: Reconstruction of the resulting defect by triple volar advancement flap: Surgical technique | [Ti{dotless}rnak-alti egzostoza baǧli{dotless} onikoklavus: Tabanda üçlü İlerletme flebi ile oluşan defektin tamiri]
Aksoy, H.M., Aksoy, B., Balci, M., Üstün, H.
Turkiye Klinikleri Journal of Medical Sciences. 2011; 31(2): 496-499
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10 The effect of gender on foot anthropometrics in older people
de Castro, A.P., Rebelatto, J.R., Aurichio, T.R.
Journal of Sport Rehabilitation. 2011; 20(3): 277-286
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11 Common nail changes and disorders in older people: Diagnosis and management
Abdullah, L., Abbas, O.
Canadian Family Physician. 2011; 57(2): 173-181
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12 Collection of biological samples in forensic toxicology
R. J. Dinis-Oliveira,F. Carvalho,J. A. Duarte,F. Remião,A. Marques,A. Santos,T. Magalhães
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13 Total nail ablation for onychodystrophy with optimized gauze-phenol application : Total nail ablation for onychodystrophy
R Becerro de Bengoa Vallejo, ME Losa Iglesias, L Alou Cervera, D Sevillano Fernández, J Prieto Prieto
Journal of the European Academy of Dermatology and Venereology. 2010; 24(8): 936
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14 Onychogryphosis | [Onicogrifosis]
Morales, P.F., Ramírez, L.M.C.
FMC Formacion Medica Continuada en Atencion Primaria. 2010; 17(2): 88
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15 Collection of biological samples in forensic toxicology
Dinis-Oliveira, R.J., Carvalho, F., Duarte, J.A., Remião, F., Marques, A., Santos, A., Magalhães, T.
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16 Nail changes and nail disorders in the elderly
Rao, S., Banerjee, S., Ghosh, S.K., Gangopadhyay, D.N., Jana, S., Mridha, K.
Indian Journal of Dermatology. 2010; 55(3): 301-304
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17 Nutrition and nail disease
Cashman, M.W., Sloan, S.B.
Clinics in Dermatology. 2010; 28(4): 420-425
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18 Nail changes in patients with liver disease
Salem, A., Gamil, H., Hamed, M., Galal, S.
Journal of the European Academy of Dermatology and Venereology. 2010; 24(6): 649-654
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19 Nutrition and nail disease
Michael W. Cashman, Steven Brett Sloan
Clinics in Dermatology. 2010; 28(4): 420
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20 Onicogrifosis
Pablo Franquelo Morales,Luis Miguel Cruz Ramírez
FMC - Formación Médica Continuada en Atención Primaria. 2010; 17(2): 88
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21 Nail changes in patients with liver disease
A Salem,H Gamil,M Hamed,S Galal
Journal of the European Academy of Dermatology and Venereology. 2009; 24(6): 649
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22 Subungual exostosis of the thumb - First case report in youngest age
Gupta, S., Mittal, A., Gupta, S., Mahendra, A., Dhull, A.
Indian Journal of Dermatology. 2009; 54(5 Suppl): S46-S48
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23 Nail debridement for the treatment of onychogryposis: Use of wire cutter and bone rongeur
Aksoy, H.M., Aksoy, B., Civaş, E., Öç, B.
European Journal of Plastic Surgery. 2008; 31(5): 269-270
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24 Dermatological findings in the senior population of nursing homes in Turkey
Kiliç, A., Gül, U., Aslan, E., Soylu, S.
Archives of Gerontology and Geriatrics. 2008; 47(1): 93-98
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25 Onychogryphosis: A case report | [Onicogrifosis: A propósito de un caso]
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26 Onicogrifosis: a propósito de un caso
L.S. Briongos-Figuero,P. Bachiller-Luque,J.M. Piqueras-Pérez
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27 Dermatological findings in the senior population of nursing homes in Turkey
Arzu Kiliç,Ülker Gül,Erkan Aslan,Seçil Soylu
Archives of Gerontology and Geriatrics. 2008; 47(1): 93
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28 Nail debridement for the treatment of onychogryposis: use of wire cutter and bone rongeur
H. M. Aksoy,B. Aksoy,E. Civas,B. Öç
European Journal of Plastic Surgery. 2008; 31(5): 269
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29 Onychomycoses chez les sujets âgés
S. Anane, O. Chtourou, A. Chedi, S. Triki, S. Belhaj, E. Kaouech, K. Kallel, E. Chaker
Annales de Dermatologie et de Vénéréologie. 2007; 134(10): 743
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30 Common Nail Disorders and Fungal Infections
Afsaneh Alavi,Kevin Woo,R. Gary Sibbald
Advances in Skin & Wound Care. 2007; 20(6): 346
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31 Onychomycosis in the elderly | [Onychomycoses chez les sujets âgés]
Anane, S., Chtourou, O., Chedi, A., Triki, S., Belhaj, S., Kaouech, E., Kallel, K., Chaker, E.
Annales de Dermatologie et de Venereologie. 2007; 134(10): 743-747
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32 Onychomycosis in the elderly: Drug treatment options
Loo DS
Drugs and Aging. 2007; 24(4): 293-302
[Pubmed]
33 Treatment of onychomycosis in diabetic patients
Winston JA, Miller JL
Clinical Diabetes. 2006; 24(4): 160-166
[Pubmed]



 

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Online since 15th March '04
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