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 STUDIES
Year : 2005  |  Volume : 71  |  Issue : 4  |  Page : 242--245

MDT-MB therapy in paucibacillary leprosy: A clinicopathological assessment


1 Departments of Dermatology, Venereology and Leprosy, Rajah Muthiah Medical College Hospital Annamalai University, Annamalai Nagar, Tamil Nadu, India
2 Departments of Pathology, Rajah Muthiah Medical College Hospital Annamalai University, Annamalai Nagar, Tamil Nadu, India

Correspondence Address:
P V S Prasad
No. 88, AUTA Nagar, Sivapuri - Post, Annamalai Nagar - 608 002, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0378-6323.16614

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BACKGROUND: The World Health Organization recommends treatment regimens for paucibacillary (PB) and multibacillary (MB) leprosy, which differ in their duration and components. Hence accurate classification of the disease is required. To overcome difficulties in classification Uniform Multi Drug Therapy (U-MDT) has been recommended. AIM : To evaluate the benefit of adding clofazimine to paucibacillary regimens in leprosy patients by measuring clinical and histological resolution. METHODS: Forty-four paucibacillary patients were included in the study. Twenty-two patients were given MDT-PB regimen and the remaining MDT-MB regimen for six months . Skin biopsies were done before the commencement and at the end of treatment. Clinical and histological resolutions were measured according to the standard criteria a laid down. The results were analyzed using Fishers' test and Crammers' V test. RESULTS: Clinical improvement was observed in 90.9% in the MB group as compared to 27.3% in the PB group. Regression in the nerve swelling was observed in 70% in the MB group and in 37.5% in the PB group while histological resolution was observed in 72.8% and 54.5% respectively. CONCLUSIONS: Addition of clofazimine helps to resolve leprosy lesions both clinically and histologically, thus justifying the concept of Uniform MDT regimen for all patients.






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