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LETTER TO EDITOR
Year : 2005  |  Volume : 71  |  Issue : 3  |  Page : 208-209

Gastric carcinoma presenting as cutaneous metastases


Department of Medical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Sector - 4, Rohini, New Delhi, India

Correspondence Address:
Kumar Prabhash
B7/99, Sector - 4, Rohini, New Delhi
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0378-6323.16245

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How to cite this article:
Prabhash K, Talwar V, Vaid A K, Doval D C. Gastric carcinoma presenting as cutaneous metastases. Indian J Dermatol Venereol Leprol 2005;71:208-9

How to cite this URL:
Prabhash K, Talwar V, Vaid A K, Doval D C. Gastric carcinoma presenting as cutaneous metastases. Indian J Dermatol Venereol Leprol [serial online] 2005 [cited 2019 Aug 22];71:208-9. Available from: http://www.ijdvl.com/text.asp?2005/71/3/208/16245


Sir,

The skin is uncommonly involved by metastatic tumors. Breast carcinoma and pulmonary carcinoma are the most common carcinomas metastasizing to the skin. Skin metastases from stomach carcinoma are uncommon. Stomach carcinoma presenting as skin metastases alone is very rare and here we report such a case.

A 50-year-old man presented with multiple nodules on the chest, back and abdomen [Figure - 1]. Fine needle aspiration cytology from the nodule was suggestive of metastatic adenocarcinoma. His upper gastrointestinal endoscopy showed an ulcero-proliferative growth at the greater curvature of the stomach, a biopsy from which showed features of adenocarcinoma of the stomach. CT scan of abdomen and chest showed thickening at the greater curvature in the stomach, while the liver and chest were normal. Colonoscopy was normal.

On the basis of these findings he was diagnosed as a case of adenocarcinoma of stomach with skin metastases. He was started on palliative chemotherapy (5-fluorouracil 750 mg/m2 on days 1-3 and cisplatin 75 mg/m2 on day 1 every three weeks). On reassessment after three cycles of chemotherapy, he was found to have progressive disease. His general condition also deteriorated. He died three months after his diagnosis.

Carcinoma stomach presenting as metastases to the skin is rare.[1] It can present as a nodule, a cellulitis like skin lesion or as an erysipelas-like picture.[2],[3] The skin metastases may be isolated or may be associated with metastases at multiple sites. As these patients have carcinoma in an advanced stage, the usual goal of therapy is palliation. Some patients may respond very well to chemotherapy.[4] Our patient had progressive disease and did not respond to chemotherapy. The survival in patients with skin metastases from a primary lesion is usually poor. The median duration of survival after skin metastases from carcinoma stomach is not known due to paucity of data. In one study the median survival was only 1.2 months.[5] This case is being reported for its rarity and to highlight the poor outcome in such patients.



 
  References Top

1.Navarro V, Ramon D, Calduch L, Llombart B, Monteagudo C, Jorda E. Cutaneous metastasis of gastric adenocarcinoma: an unusual clinical presentation. Eur J Dermatol 2002;12:85-7.  Back to cited text no. 1  [PUBMED]  [FULLTEXT]  
2.Foo KF, Tao M, Tan EH. Gastric carcinoma presenting with cellulites - like cutaneous metastasis. Singapore Med J 2002;43:37-8.  Back to cited text no. 2  [PUBMED]    
3.Carreno MR, Munoz YT, Ibanez PA, Munoz GR, Polimon OI, Benito BA, et al. Erysipeloid skin metastasis as presentation form of gastric cancer. Rev Esp Enferm Dig 2001;93:672-3.  Back to cited text no. 3      
4.Michiwa Y, Earashi M, Kobayashi H, Matsuki N. Cutaneous metastases from gastric adenocarcinoma treated with combination chemotherapy producing complete response with long survival. J Exp Clin Cancer Res 2001;20:297-9.  Back to cited text no. 4  [PUBMED]    
5.Schoenlaub P, Sarraux A, Grosshans E, Heid E, Cribier B. Survival after cutaneous metastasis: A study of 200 cases. Ann Dermatol Venereol 2001;128:1310-15.  Back to cited text no. 5  [PUBMED]  [FULLTEXT]  


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This article has been cited by
1 Gastric carcinoma with skin metastasis | [Carcinoma gástrico con metástasis en la piel]
González-Paredes, G.M.
Piel. 2008; 23(9): 529-531
[Pubmed]
2 Carcinoma gástrico con metástasis en la piel
Gabriela M. González-Paredes
Piel. 2008; 23(9): 529
[Pubmed] | [DOI]



 

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