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Year : 2005  |  Volume : 71  |  Issue : 2  |  Page : 112--114

Hyper IgE syndrome: Report of two cases with moderate elevation of IgE

Department of Dermatology and Venereology, Medical College, Kozhikode, India

Correspondence Address:
K Muhammed
Kunnummal House, Koroth School Road, Vadakara, Kozhikode - 673101, Kerala
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0378-6323.13997

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Hyper IgE syndrome with recurrent infection (Job's syndrome) is a rare idiopathic primary immunodeficiency disease characterized by the triad of elevated serum IgE (>2000 IU/ml), recurrent cutaneous abscesses and recurrent sinopulmonary infections. The bacteria which commonly infect these patients are Staphylococcus aureus and Haemophilus influenzae. Therapy should include prolonged antibiotic therapy and early surgery. Non-specific agents like levamisole and ascorbic acid may reduce recurrent infections. We are reporting two girls, six and twelve years of age, presented with recurrent cutaneous and respiratory infections and moderately elevated levels of serum IgE.


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Online since 15th March '04
Published by Wolters Kluwer - Medknow