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Year : 2004  |  Volume : 70  |  Issue : 6  |  Page : 345--348

Management of premenstrual acne with Cox-2 inhibitors: A placebo controlled study

1 Consultant Dermatologist, Mallya Hospital, Bangalore, India
2 Dept. of Endocrinology, M. S. Ramaiah Medical College, Bangalore - 560 054, India

Correspondence Address:
Rustom Tehrani
’Citadel’, 11 Plain Street, Shivajinagar, Bangalore - 560001
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Source of Support: None, Conflict of Interest: None

PMID: 17642660

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BACKGROUND: Premenstrual acne is poorly understood, the accepted hypothesis is 30 years old. AIMS: Here we test the hypothesis that premenstrual acne can be suppressed using Cox-2 inhibitors. METHODS: Eighty women with premenstrual acne were enrolled in a trial where they were given rofecoxib, a Cox-2 inhibitor or placebo for 10 days for two cycles and were evaluated using acne severity index and inflammatory acne counts. RESULTS: Rofecoxib was more effective than the placebo. CONCLUSIONS: Although the number studied is small, the results suggest that rofecoxib is effective in the management of premenstrual acne and that prostaglandin PGE2 may be involved in its pathogenesis.


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Online since 15th March '04
Published by Wolters Kluwer - Medknow