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 CASE REPORT
Year : 2004  |  Volume : 70  |  Issue : 5  |  Page : 300--303

Darier's disease following radiotherapy for carcinoma of cervix


1 Tata Memorial Centre, Mumbai, India
2 Johannesburg Hospital, Johannesburg, South Africa
3 Department of Dermatology, Seth G. S. Medical College and KEM Hospital, Mumbai, India

Correspondence Address:
Supriya Chopra
#110, Old building, Tata Hospital, Parel, Mumbai - 400012
India
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Source of Support: None, Conflict of Interest: None


PMID: 17642644

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Darier-White disease is due to a defect in the ATP2A2 gene encoding the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA2b). We report a case of carcinoma cervix in whom Darier's disease manifested after the initiation of radiation therapy. Conventional cytogenetics on peripheral blood revealed non-clonal constitutional autosomal and X chromosome abnormalities suggesting radiation induced gene toxicity. Occurrence of Darier's disease in our case could be due to treatment induced sustained differentiation in the Darier's affected skin by an unknown mechanism. Late onset or sporadic Darier's disease is the other possibility.






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Online since 15th March '04
Published by Wolters Kluwer - Medknow