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Year : 2004  |  Volume : 70  |  Issue : 4  |  Page : 221--225

Skin changes in internal malignancy

1 Dept of Dermatology, 5 Air Force Hospital, C/o 99 APO, India
2 Former Prof & Head, Dept. of Dermatology, Command Hospital (SC), Pune, India
3 Dept. of Dermatology, Command Hospital (AF) Bangalore, India

Correspondence Address:
Ravi Rajagopal
Dept. of Dermatology, 5 Air Force Hospital, C/o 99 APO
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Source of Support: None, Conflict of Interest: None

PMID: 17642619

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BACKGROUND: Internal malignancies are accompanied by various skin changes which may be specific infiltrates or non-specific changes. This study is aimed at determining the frequency of such changes in malignant disease treatment center attendees in India. METHODS: A study of 300 confirmed cases of internal malignancy at a malignant disease treatment center was undertaken to evaluate these skin changes. Specific infiltrates were confirmed by histopathology. Statistical methods were employed to calculate significance in non-specific lesions by comparing with 300 controls not suffering from internal malignancy. RESULTS: Skin changes were present in 82 (27.3%). Cutaneous metastases were found in 19 (6.3%); non-contiguous in 5 (1.6%); contiguous in 14 (4.3%). Non-specific skin lesions numbered 74 (11.6%) in 52 patients. Statistically significant non-specific skin changes were acquired ichthyosis, herpes zoster and generalized pruritus. CONCLUSION: Metastases usually occurred late in internal malignancy (17, 5.6%) except in a case each of histiocytic lymphoma and non-Hodgkin's lymphoma (2, 0.7%) where the lesions preceded malignancy by 3 months and 1 month respectively. Contiguous nodules were a marker of relapse after surgery in 3 (1%).


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Online since 15th March '04
Published by Wolters Kluwer - Medknow