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LETTER TO EDITOR
Year : 2003  |  Volume : 69  |  Issue : 5  |  Page : 363-364
 

Response by the authors


Deartment of Skin & STD, Kasturba Medical College & Hospital, Manipal

Correspondence Address:
Deartment of Skin & STD, Kasturba Medical College & Hospital, Manipal



How to cite this article:
Prabhu S, Shenoi S D. Response by the authors. Indian J Dermatol Venereol Leprol 2003;69:363-4


How to cite this URL:
Prabhu S, Shenoi S D. Response by the authors. Indian J Dermatol Venereol Leprol [serial online] 2003 [cited 2019 Jul 18];69:363-4. Available from: http://www.ijdvl.com/text.asp?2003/69/5/363/5761


Sir,
We wish to thank Dr M. J. Cyriac for spotting the error and enlightening the readers about the interaction of cyclosporin with grapefruit and not grape juice. We are happy that our article has been thoroughly scrutinized.

A point to be noted is that although sweet orange juice is safe, a variety of sour oranges used in marmalades called Seville oranges contain 6,7 dihydroxybergamottin, the furanocoumarin compound found in grapefruit. However a recent study[1] has not found interaction of Seville orange juice with cyclosporine. 

      References Top

1.Edwards DJ, Fitzsimmons ME, Schuetz EG et al. 6, 7 dihydroxybergamottin in grapefruit juice and Seville orange juice: effects on cyclosporine disposition, enterocyte CYP3A4 and P-glycoprotein. Clin Pharmacol Ther 1999;65:237-44.  Back to cited text no. 1    

 

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